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Glucagon-like peptide 1 receptor agonist use and risk of thyroid cancer: Scandinavian cohort study

Objective To investigate whether use of glucagon-like peptide 1 (GLP1) receptor agonists is associated with increased risk of thyroid cancer.

Design Scandinavian cohort study.

Setting Denmark, Norway, and Sweden, 2007-21.

Participants Patients who started GLP1 receptor agonist treatment were compared with patients who started dipeptidyl peptidase 4 (DPP4) inhibitor treatment, and in an additional analysis, patients who started sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment.

Main outcome measures Thyroid cancer identified from nationwide cancer registers. An active-comparator new user study design was used to minimise risks of confounding and time related biases from using real world studies of drug effects. Cox regression was used to estimate hazard ratios, controlling for potential confounders with propensity score weighting.

Results The mean follow-up time was 3.9 years (standard deviation 3.5 years) in the GLP1 receptor agonist group an ....

United States , Karolinska Institutet , Eli Lilly , Drottning Victorias Frimurarestiftelse , Konung Gustaf , Swedish Research Council , European Medicines Agency , Lundbeck Foundation , Drug Administration , Danish Cancer Society , Swedish Cancer Society , Boehringer Ingelheim , Novo Nordisk Foundation , World Health Organization , Research Foundation Denmark , Novo Nordisk , Independent Research Foundation Denmark , Merck Sharp , Open Access , Creative Commons Attribution ,

Improvement to CRISPR gene editing could make it more effective: The finding opens the technology to wider use for more diseases

Improvement to CRISPR gene editing could make it more effective: The finding opens the technology to wider use for more diseases
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Telmo Llanga , Korie Bush , Amyc Yan , Giulia Corsi , Julianam Layzer , Bruce Sullenger , Keith Haynes , Jan Gorodkin , Jonathanh Zhou , Duke Health , Novo Nordisk Foundation , Research Foundation Denmark , National Institutes Of Health , Cell Chemical Biology , Distinguished Professor , Experimental Surgery , Duke University School , Cancer Biology , Cell Biology , National Institutes , Independent Research Foundation Denmark ,

Can CRISPR gene editing be improved? Yes, says Duke Health researchers

CRISPR gene editing is a breakthrough that has been used to treat diseases such as sickle cell anemia, leukemia and genetic disorders, but it has challenges that limit its broad utility. Let's take a look. ....

Amyc Yan , Giulia Corsi , Jonathanh Zhou , Bruce Sullenger , Korie Bush , Keith Haynes , Julianam Layzer , Telmo Llanga , Jan Gorodkin , Novo Nordisk , National Institutes Of Health , Duke Health , Research Foundation Denmark , Cell Chemical Biology , Distinguished Professor , Experimental Surgery , Duke University School , Cancer Biology , Cell Biology , National Institutes , Independent Research Foundation Denmark ,