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Gene Variant Points to Starvation's Evolutionary Legacy | The Scientist Magazine®

Gene Variant Points to Starvation's Evolutionary Legacy | The Scientist Magazine®
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United States , San Francisco , Tony Capra , Omer Gokcumen , Gil Atzmon , University Of California , Rebecca Farnham Marie Saitou University At Buffalo , Albert Einstein College Of Medicine , University Of Haifa , University At Buffalo , Science Advances , Integrative Genomics Viewer , Marie Saitou , Upper Paleolithic , Albert Einstein College ,

Multiform antimicrobial resistance from a metabolic mutation

A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment by persistence or tolerance. Seeking mechanisms behind such high survival, we developed a forward-genetic method for efficient isolation of high-survival mutants in any culturable bacterial species. We found that perturbation of an essential biosynthetic pathway (arginine biosynthesis) in a mycobacterium generated three distinct forms of resistance to diverse antibiotics, each mediated by induction of WhiB7: high persistence and tolerance to kanamycin, high survival upon exposure to rifampicin, and minimum inhibitory concentration–shifted resistance to clarithromycin. As little as one base change in a gene that encodes, a metabolic pathway component conferred multiple forms of resistance to multiple antibiotics with different targets. This extraordinary resilience may help explain how substerilizing exposure to one antibiotic in a regimen can induce resistance to ....

City Of , United Kingdom , Beckman Coulter , Roche Lightcycler , Dnase Ambion , Fortune Lab , Institutionald Program , Broad Institute , Us Department Of Defense , National Institute Of Allergy , Sciences Of The National Institutes Health , National Defense Science , L Botella Francis Crick Institute , Scientist Training Program , Imperial College London , Potts Memorial Foundation , Rockefeller University , Pfizer External Sciences , European Commission Marie Sk , Centre For Molecular Bacteriology , National Institute , Tres Cantos Open Lab Foundation , National Center , Howard Milstein Program In Chemical Biology , National Institutes Of Health , World Health Organization ,

Ancient DNA reveals multiple origins and migration waves of extinct Japanese brown bear lineages

Ancient DNA reveals multiple origins and migration waves of extinct Japanese brown bear lineages
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United States , Japan General , Tsugaru Strait , Royal Society , Arkhangel Skaya Oblast , Monte Carlo , Shigeru Kobayashi , Hiromichi Kitagawa , Jiaqi Wu , Jesper Stenderup , Hiseq Xten , University Of Copenhagen , Saitama Museum Of Natural History , National Institute Of Polar Research , National Institute Of Genetics , Genomics Institute , Institute Of Statistical Mathematics , Research Organization Of Information , Danish National High , Japan Society For The Promotion Of Science , Scientific Research , Centre For Geogenetics , Kyoto University , Wildlife Research Center , National Museum Of Nature , Library Prep Master Mix ,

Frontiers | Genomic Diversity of the Ostreid Herpesvirus Type 1 Across Time and Location and Among Host Species

Frontiers | Genomic Diversity of the Ostreid Herpesvirus Type 1 Across Time and Location and Among Host Species
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New York , United States , United Kingdom , La Tremblade , Poitou Charentes , Fig Tree , New South Wales , Adriatic Sea , Oceans General , Scapharca Anadara , Max Carvalho , Le Guyader , Genotoul Toulouse , Laure Quintric , Van Damme , Patrick Durand , Zealand Segarra , Isabelle Arzul , Santos Loureiro , Mbong Ngwese , Van Loock , Malacoherpesviridae Rosani , La Monte Carlo , Xied Rambaut , Moeller Trane , Genomic Library Preparation ,