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7,8 and organ protection from ischemia/reperfusion injury. 9,10 Newly synthesized transition metal carbonyl-compounds, CO release molecules (CORMs), are effective in regulating CO release in vivo and in vitro in appropriate circumstances. 11 These CO releasing molecules can therefore be used as the new carrier to provide exogenous CO. CORM-3 [tricarbonylchloro (glycinato) ruthenium (II)] is completely soluble in water with fast release of CO when dissolved in a physiological solution. By releasing CO, CORMs also induce an anti-inflammatory effect. Our previous study showed that CORM-2 reduced periodontal inflammation and alveolar bone resorption in rats with experimental periodontitis. 13 We also reported CORM-3 suppressed the expression of adhesion molecules in human gingival fibroblasts co-stimulated by tumor necrosis factor-α and interleukin-1 β, ....
Junjie Li, Wenya Bai, Peihua Peng, Wendong Chen, Wei Yang, Jianlin Shao Department of Anesthesiology, First Affiliated Hospital, Kunming Medical University, Kunming City, 650032, People’s Republic of China These authors contributed equally to this work Correspondence: Jianlin Shao Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Wuhua, Kunming, Yunnan, 650000, People’s Republic of China Tel +86-871-6532488-2755 Background: We have previously demonstrated that biliverdin has neuroprotective effects that ameliorate cerebral ischemia/reperfusion (I/R) injury in rats. However, the underlying mechanism is unknown. This study aimed at elucidating on the modulatory role of miR-27a-3p on Rgs1 as a mechanism by which biliverdin affects cerebral I/R injury. ....
for a reduced atmosphere on ancient Mars The blue-toned rocks in the upper-left of the image are depleted in iron because it was removed during weathering on ancient Mars. This is geological evidence that iron was lost from the rocks in reduced conditions. Both Earth and Mars currently have oxidising atmospheres, which is why iron-rich materials in daily life develop rust (a common name for iron oxide) during the oxidation reaction of iron and oxygen. The Earth has had an oxidising atmosphere for approximately two and a half billion years, but before that, the atmosphere of this planet was reducing – there was no rust. ....
Self-driving service revolutionizing urban transportation China Daily | Updated: 2021-01-06 09:38 Share CLOSE A self-driving taxi is parked on a street in Changsha, Hunan province, on Aug 6. [Photo/Xinhua] CHANGSHA－A white car parked on a wide street in Changsha, capital of Central China s Hunan province, awaits passengers. However, there s something unusual about this ordinary-looking taxi－it has no driver. In April, Changsha became the first in the country to roll out the self-driving taxi service for the public. Though the service is currently limited to a selected part in the city, mainly covering residential communities, commercial areas and industrial parks, Changsha has nevertheless been dubbed the City of Intelligent Driving for unveiling such cutting-edge technology for public consumption. ....
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