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Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works
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Rafael Fern , Titia Sixma , Meindert Lamers , Emily Henderson , Spanish National Cancer Research Centre , Loncode Institute , Leiden University Medical Center , Structural Biology Group , Netherlands Cancer Institute , Genomic Integrity , Nature Structural , ரஃபேல் ஃபெர்ன் , எமிலி ஹென்டர்சன் , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் , கட்டமைப்பு உயிரியல் குழு , நெதர்லாந்து புற்றுநோய் நிறுவனம் , இயற்கை கட்டமைப்பு ,

An international study reveals how the 'guardian' of the genome works

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IMAGE: The background of the illustration is a photograph taken with the electron microscope showing DNA molecules decorated with MutS molecules, scanning the DNA for errors. The lower part shows.
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Credit: CNIO
Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre (CNIO) have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication. Using cryo-electron microscopy, they made the MutS protein, also known as the guardian of our genome, visible. That enabled them to describe how this single protein is able to coordinate the essential DNA repair process from beginning to end. ....

United Kingdom , Spanish State , Rafael Fern , Titia Sixma , Meindert Lamers , United Kingdom Medical Research Council , Spanish State Agency For Innovation , Spanish Ministry Of Science , Structural Biology Group , Spanish National Cancer Research Centre , Loncode Institute , Leiden University Medical Center , Netherlands Cancer Institute , Institute Of Health , Genomic Integrity , Nature Structural , Spanish Ministry , Spanish State Agency , ஒன்றுபட்டது கிஂக்டம் , ஸ்பானிஷ் நிலை , ரஃபேல் ஃபெர்ன் , ஒன்றுபட்டது கிஂக்டம் மருத்துவ ஆராய்ச்சி சபை , ஸ்பானிஷ் அமைச்சகம் ஆஃப் அறிவியல் , கட்டமைப்பு உயிரியல் குழு , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் , நெதர்லாந்து புற்றுநோய் நிறுவனம் ,

Descubren cómo funciona la "guardiana" de nuestro genoma

Descubren cómo funciona la "guardiana" de nuestro genoma
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Cancer Research , Institute Of Health Karl , Loncode Institute , Leiden University Medical Center , Group Of Integrity Genomics , Centre Of Cancer Research , Nature Structural , Integrity Genomics And , Runs Rafael , Raphael Explained , Health Karl , State Agency , புற்றுநோய் ஆராய்ச்சி , இயற்கை கட்டமைப்பு ,

Descubren cómo funciona la proteína "guardiana" del genoma humano

Descubren cómo funciona la proteína "guardiana" del genoma humano
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Cancer Research , Institute Of Health Karl , Loncode Institute , Leiden University Medical Center , Group Of Integrity Genomics , Centre Of Cancer Research , Nature Structural , Integrity Genomics And , Runs Rafael , Raphael Explained , Health Karl , State Agency , புற்றுநோய் ஆராய்ச்சி , இயற்கை கட்டமைப்பு ,

SkylineDx, Oncode Institute and Utrecht Holdings sign license agreement for innovative algorithm RAINFOREST

SkylineDx, Oncode Institute and Utrecht Holdings sign license agreement for innovative algorithm RAINFOREST
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ROTTERDAM, Netherlands and SAN DIEGO, Feb. 23, 2021 /PRNewswire/ Today, SkylineDx announces to have signed a license agreement with Oncode Institute and Utrecht Holdings on a shared patent covering the innovative algorithm RAINFOREST. This algorithm is based on Random Forest, a specific machine learning method, and is able to identify subgroups of patients that will benefit more than the population as a whole from a certain treatment
[2]. The performance of this algorithm is demonstrated on a dataset from a phase III (last phase of medicine research) colorectal cancer study. This study did not show any benefit for the drug (Cetuximab) under investigation, meaning that patients had the same risk of progressing whether they would have received Cetuximab or not. RAINFOREST, however, was able to identi ....

United States , The Netherlands , Ian Bell , Dharminder Chahal , Nature Communications , Loncode Institute , Utrecht University , University Medical Center , Muu Holding , Utrecht Holdings , Random Forest , Jeroen De Ridder , Oncode Investigator Jeroen De Ridder , Interim Valorization Director , San Diego , ஒன்றுபட்டது மாநிலங்களில் , தி நெதர்லாந்து , ஈயந் மணி , தர்மிந்தர் சாஹல் , இயற்கை தகவல்தொடர்புகள் , அட்ரெக்ட் பல்கலைக்கழகம் , பல்கலைக்கழகம் மருத்துவ மையம் , அயூ வைத்திருத்தல் , அட்ரெக்ட் ஹோல்டிங்ஸ் , சீரற்ற காடு , சான் டியாகோ ,