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Rationale: Extracellular histones, released into the surrounding environment during extensive cell death, promote inflammation and cell death, and these deleterious roles have been well documented in sepsis. Clusterin (CLU) is a ubiquitous extracellular protein that chaperones misfolded proteins and promotes their removal. Objectives: We investigated whether CLU could protect against the deleterious properties of histones. Methods: We assessed CLU and histone expression in patients with sepsis and evaluated the protective role of CLU against histones in in vitro assays and in vivo models of ex...

Violence, Insecurity, and Displacement in Alto Mira y Frontera Community Council, Tumaco, Nariño Armed or criminal groups, including new groups that emerged or took over territory after the demobilization of the FARC, are responsible for violence and restrictions on movement in and around Alto Mira y Frontera and other communities around Tumaco municipality. These groups, including especially groups involved in the drug trade and other illegal economies with an interest in the land around rural

Tom Drane takes victory at the DuQuoin Mile, with Max Whale just missing a podium position in fourth. Mees claiming the Supertwins victory...

The 6th edition of the African Forum of Territorial Managers and Training Institutes targeting Territorial Communities (FAMI 6_2022) opened its work in

(Archived document, may contain errors) 142 May 14, 1981 THE INFANT FORMULA CONTROVERSY INTRODUCTION The running controversy over infant formula promotion and sales in the Third World moves into a new phase this month as the World Health Assembly meets in Geneva to consider the adoption of a code r egulating the marketing of breast milk substitutes. The proposed International Code of Marketing for Breastmilk Substitutes has drawn criticism from industry and government.