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Mobile Virtual Network Operator (MVNO) Market Size to Worth USD 138.34 billion by 2030 With a 8.5% CAGR

Mobile virtual network operator (MVNO) market is expected to grow at 8.5% CAGR from 2022 to 2029. It was valued 66.38 billion at 2020. It is expected to reach above USD 138.34 billion by 2029.

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Adaptive Optics Market Size to Worth USD 3101.73 million by 2030 With a 25.8% CAGR

The global adaptive optics market was valued at 622.07 million in 2022 and is projected to reach USD 3101.73 million by 2029, growing at a CAGR of 25.8% from 2022 to 2029.

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The estimands framework: a primer on the ICH E9(R1) addendum

Estimands can be used in studies of healthcare interventions to clarify the interpretation of treatment effects. The addendum to the ICH E9 harmonised guideline on statistical principles for clinical trials (ICH E9(R1)) describes a framework for using estimands as part of a study. This paper provides an overview of the estimands framework, as outlined in the addendum, with the aim of explaining why estimands are beneficial; clarifying the terminology being used; and providing practical guidance on using estimands to decide the appropriate study design, data collection, and estimation methods. This article illustrates how to use the estimands framework by applying it to an ongoing trial in emergency bowel surgery. Estimands can be a useful way of clarifying the exact research question being evaluated in a study, both to avoid misinterpretation and to ensure that study methods are aligned to the overall study objectives.

Research studies are often used to answer questions about the effect of an intervention. However, deciding on the precise research question to ask, or how best to design the study to answer that question, can be challenging. Consider the FLO-ELA trial, a pragmatic trial comparing two methods of fluid delivery (cardiac output monitor v clinician judgment) in patients undergoing emergency bowel surgery.1 Because of the lead-in time required to prepare the intervention, a small delay between randomisation and the start of surgery is necessary, and so some participants in FLO-ELA could have their surgery cancelled after randomisation, either because they become too unwell or the underlying issue has resolved itself.

A standard approach for pragmatic trials is to conduct an intention-to-treat analysis, which would include participants who did not undergo surgery.2 However, consideration of the research question could lead investigators to question this approach. An intention-to-treat analysis answers the question “What is the difference between …

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OLED Panel Market Research [2024-2031] | Global Business Development, Growth, Trends, Market Overview, Covid-19 Impact Analysis With Industry Synopsis

OLED Panel Market Research [2024-2031] | Global Business Development, Growth, Trends, Market Overview, Covid-19 Impact Analysis With Industry Synopsis
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Electrocautery Devices Market Global Sales, Revenue, Trends, Growth, Future Prospects By Players Price And Gross Margin Forecast To 2031

Electrocautery Devices Market Global Sales, Revenue, Trends, Growth, Future Prospects By Players Price And Gross Margin Forecast To 2031
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2030, Calcineurin Inhibitor Drug Market Statistical Surveying 2023 Review Incorporates Recognizing Contenders, Examining Their Assets And Shortcomings...

2030, Calcineurin Inhibitor Drug Market Statistical Surveying 2023 Review Incorporates Recognizing Contenders, Examining Their Assets And Shortcomings...
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Polycarbonate Glazing Market Innovations And Developments Till 2030 | 108 Pages Report

Polycarbonate Glazing Market Innovations And Developments Till 2030 | 108 Pages Report
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Exploring The Growth Potential Of The Aluminum Plates And Sheets Market Till 2030 | 120 Pages Report

Exploring The Growth Potential Of The Aluminum Plates And Sheets Market Till 2030 | 120 Pages Report
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Power Source Analyzers Market Analysis And Forecast To 2030 | 97 Pages Report

Power Source Analyzers Market Analysis And Forecast To 2030 | 97 Pages Report
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