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3D biopsies to better understand brain tumors

3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències obtained a highly accurate recreation of human glioblastoma’s features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies.
This new analysis of 3D images and quantitative data “will help to appreciate from within how the tumor is built in its full dimensionality, and to identify where different cell types are located”, explains George Paul Cribaro, first author of the study. “It provides more complete information than the usual 2D analyses performed for neuropathological diagnosis” ....

George Paul Cribaro , Carlos Barcia , Acta Neuropathologica Communications , Institut De Neuroci , Autonomous University Of Barcelona , Athe Entrance , Blood Vessels , Immune Cells , தன்னாட்சி பல்கலைக்கழகம் ஆஃப் பார்சிலோனா , தி நுழைவு , இரத்தம் நாளங்கள் , நோய் எதிர்ப்பு சக்தி செல்கள் ,

Doctors Warn That COVID-19 Will Become Endemic. Here's What That Means

Updated on February 24, 2021 at 5:05 pm
NBC Universal, Inc.
The novel coronavirus has changed lives, economies and health care systems as we know it.
On March 11, 2020, the World Health Organization classified COVID-19 as a pandemic. The respiratory virus that originated in China has since infected tens of millions of people worldwide, and killed more than 2 million.
Get the answer to your most-asked COVID vaccine questions on our mobile NBC 5 Chicago app. Download it here for iOS or Android.
Since the WHO s classification, the United States and other countries have taken drastic steps to attempt to slow the spread of the virus. From sheltering in place to travel restrictions to full border closures, the global pandemic has affected nearly every aspect of daily life. ....

United States , United Kingdom , Gavin Newsom , Mike Ryan , Los Angeles , Donald Trump , Eric Garcetti , Cambridge University , Centers For Disease , World Health Organization , Disease Control , Middle East Respiratory Syndrome , Severe Acute Respiratory Syndrome , President Donald Trump , Los Angeles Mayor Eric Garcetti , Social Distancing , Health Organization , United Nation , Covid 19 , Care Facility , United Nations Amp , Border Closures , Community Spread , Coronavirus Outbreak , Corona Virus , Health Care Systems ,

New collaborative project to study the complex roles of lipids in health, disease

New collaborative project to study the complex roles of lipids in health, disease
A University of Minnesota-Mayo Clinic partnership has joined with the Zooniverse citizen scientist platform and the Francis Crick Institute in London to leverage world-leading expertise in microscope imaging with the power of citizen science to study the relationship between structure and function in biology to better understand health and disease.
The Minnesota Microscopy Infrastructure Partnership, led by the Mayo Clinic, the University of Minnesota, and the University s Hormel Institute, serves the high-end optical and electron microscope needs of more than 400 research laboratories in Minnesota and surrounding states. The collaboration is supported by the State of Minnesota. ....

United States , University Of Minnesota , City Of , United Kingdom , State Of Minnesota , Douglas Mashek , Emily Henderson , College Of Science , University Hormel Institute , A University Of Minnesota , Department Of Biochemistry , University Of Minnesota Professor Lucy Fortson , Founder Of Minnesota Microscopy Infrastructure Partnership , University School Of Physics , Minnesota Microscopy Infrastructure Partnership , Cell Analysis Laboratory , University Of Minnesota Medical School , Francis Crick Institute , Minnesota Mayo Clinic , Mayo Clinic , Hormel Institute , Microscopy Infrastructure Partnership , Project Leader , Scientific Director , Mayo Clinic Microscopy , Cell Analysis ,

Scientists reveal the structure of glutamate transporter in our cells

Scientists reveal the structure of glutamate transporter in our cells
Feb 18 2021
For the first time, researchers have found one of the most important molecular machines in our cells uses a ‘twisting elevator’ mechanism, solving a mystery of how it transports crucial chemical signals from one cell to another.
Individual transporter particles captured by the cryo-EM (left), the structure solved by averaging thousands of these individual particles (middle) and a computer simulation of the glutamate transporter in a lipid membrane revealing the pathway for chloride ions (red) (right; image credit, Shashank Pant, University of Illinois at Urbana-Champaign)
A University of Sydney-led international team of scientists has revealed the shape of one of the most important molecular machines in our cells – the glutamate transporter – helping to explain how our brain cells communicate with one another. ....

United States , New South Wales , Ichia Chen , Qianyi Wu , Renae Ryan , University Of Illinois At Urbana Champaign , School Of Medical Sciences , University Of Sydney , Shashank Pant , Medical Sciences , Sydney Microscopy , Cell Membrane , Electron Microscopy , ஒன்றுபட்டது மாநிலங்களில் , புதியது தெற்கு வேல்ஸ் , ரெனே ரியான் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் இல் ஊர்பன சாம்பியன் , பள்ளி ஆஃப் மருத்துவ அறிவியல் , பல்கலைக்கழகம் ஆஃப் சிட்னி , ஷாஷாங்க் பாண்ட் , மருத்துவ அறிவியல் , சிட்னி நுண்ணோக்கி , செல் சவ்வு , எதிர் மின்னணு , எதிர் மின்னணு நுண்ணோக்கி , வளர்சிதை மாற்றம் ,

3D microscopy sheds light on the body's immune response to obesity

3D microscopy sheds light on the body’s immune response to obesity
Researchers who focus on fat know that some adipose tissue is more prone to inflammation-related comorbidities than others, but the reasons why are not well understood. Thanks to a new analytical technique, scientists are getting a clearer view of the microenvironments found within adipose tissue associated with obesity.
This advance may illuminate why some adipose tissues are more prone to inflammation - leading to diseases like type 2 diabetes, cancer and cardiovascular disorders - and help direct future drug therapies to treat obesity.
In a new study, University of Illinois Urbana Champaign bioengineering professors Andrew Smith and Mark A. Anastasio, molecular and integrative physiology professor Erik Nelson and nutritional sciences professor Kelly Swanson detail the use of the new technique in mice. The results are published in the journal ....

Marka Anastasio , Andrew Smith , Kelly Swanson , Erik Nelson , Emily Henderson , University Of Illinois Urbana Champaign , Illinois Urbana Champaign , Illinois Urbana , Analytical Technique , Type 2 Diabetes , மார்க்கா அனஸ்டசிோ , ஆண்ட்ரூ ஸ்மித் , கெல்லி ஸ்வான்சன் , ஏறிக் நெல்சன் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் ஊர்பன சாம்பியன் , இல்லினாய்ஸ் ஊர்பன சாம்பியன் , இல்லினாய்ஸ் ஊர்பன , உடல் பருமன் , பகுப்பாய்வு நுட்பம் , நீரிழிவு நோய் ,