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Estimands can be used in studies of healthcare interventions to clarify the interpretation of treatment effects. The addendum to the ICH E9 harmonised guideline on statistical principles for clinical trials (ICH E9(R1)) describes a framework for using estimands as part of a study. This paper provides an overview of the estimands framework, as outlined in the addendum, with the aim of explaining why estimands are beneficial; clarifying the terminology being used; and providing practical guidance on using estimands to decide the appropriate study design, data collection, and estimation methods. ...

The delay in the CDC’s mortality data means it may take months before researchers can access a rich and intimate measure of how people in America die.

What are the benefits of artificial intelligence? We must begin by understanding AI within the context of international relations.

Public schools lack the resources to track their facilities and operations, resulting in missed opportunities for equitable learning environments.

“Today, we remind law enforcement of their responsibility to safeguard this data and ensure its use is consistent with state law,” the attorney general said.