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1* 1Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, United States 2Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, United States 3Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States 4Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, United States Tumor-stromal interactions within the tumor microenvironment (TME) influence lung cancer progression and...

−1), which is consistent with the results in HepG2 cells (0.2–2 mg·mL −1), 55 but promoted cell proliferation at low concentrations in vitro. Notably, the cell viability was greater than 60% when the CS-CD concentration was less than 4.5 µg•mL −1, which may be desired (regeneration, neurogenesis, etc.) or undesired (tumours and cancers) cell proliferation. Because the type of cell proliferation is unknown, it is difficult to determine whether toxicity is high or low. Further study on cell proliferation is required. However, the results only indicated that the cytotoxicity of CS-CD...

Discussion There are several therapeutic approaches to bio-functional foods against cardiovascular diseases, both in experimental and clinical studies. Germinated Brown Rice (GBR) exerted its protective properties on cardiovascular diseases and related-cardiovascular metabolism dysfunction, including hypertension, hyperlipidemia, and diabetes. Here, this is the first study to represent the cardioprotective effect of GBR on cardiomyocyte-simulated I/R injury. The significant findings in this study indicated that simulation of I/R promoted the percentage of cell death and total cell apoptosis. ...

Figure 1 Construction of occludin/ZO1 probes and analysis of their efficacy and motility. ( A) In cpstFRET (cpVenus-7aa-cpCerulean), cpCerulean (cyan) is the donor and cpVenus (yellow) is the acceptor. The probes have high Förster resonance energy transfer (FRET) efficiency when donor and acceptor are parallel without external force (f: external force). The external force reduces the FRET efficiency by changing the angle of cpstFRET. ( B) Schematic representation of the occludin/ZO1 probe constructs. The cpstFRET module was inserted between amino acids 357 and 358 in the occludin probe and b...

2Laboratory for Pharmaceutical Biotechnology, University of Ghent, Ghent, Belgium 3ProGenTomics, Ghent, Belgium 4Laboratory of Proteinscience, Proteomics and Epigenetic Signaling, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium 5Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium Chikungunya virus (CHIKV) is an arbovirus with a global spread and significant public health impact. It is a positive stranded RNA alphavirus belonging to the Togaviridae family. However, many questions about the replication cycle of CHIKV...