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G) The mRNA and ( H, I) protein levels of CCND1 were determined by Real-Time qPCR and Western Blot analysis, respectively. (Note: “Con” indicated “Control”, “KD-L” indicated “Knock-down of LncRNA SNHG16” and “KD-L+KD-miR” suggested “both LncRNA SNHG16 and miR-17-5p ablation”). Each experiment repeated at least 3 times, and * P 0.05. Knock-Down of LncRNA SNHG16 Inhibited OSCC Progression Through the miR-17-5p/CCND1 Axis We next investigated whether LncRNA SNHG16 regulated OSCC development by targeting the miR-17-5p/CCND1 axis. To achieve this, the LncRNA SNHG16 silen...

Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro Martina Morokutti-Kurz, Affiliation Marinomed Biotech AG, Korneuburg, Austria ⨯ Maria Fröba, Affiliation Institute of Virology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany ⨯ Philipp Graf, Affiliation Marinomed Biotech AG, Korneuburg, Austria ⨯ Maximilian Große, Affiliation Institute of Virology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany ⨯ Andreas Grassauer, Affiliation Marinomed Biotech AG, Korneuburg, Aus...

G), invasion rate ( H, I) in vitro model of LNCap cell. *p 0.01 compared with negative group, #p 0.01 compared with down-regulation of RAMS11 group. Abbreviations: Negative, negative mimics group; SiRAMS11, down-regulation of RAMS11 group; Top2α, over-expression of Top2α group. Discussion The treatment of prostate cancer is mainly determined by objective factors, including patient age, physical condition, clinical stage, Gleason score, presence or absence of pelvic lymph nodes, distant metastases, and life expectancy. 18 At present, there are various therapeutic methods for prostate cancer...

1 1Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, People’s Republic of China; 2Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, Liaoning, People’s Republic of China Correspondence: Rui Ma Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, People’s Republic of China Background: Lung cancer is one of the most aggressive tumors with high incid...