Stay updated with breaking news from Open Access. Get real-time updates on events, politics, business, and more. Visit us for reliable news and exclusive interviews.
Ministers are trying to blame the Train Operating Companies (TOCs) for failing to make use of the new Minimum Service Regulations in their continuing – now two years in – dispute with Aslef.
Objective To evaluate the comparative efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycaemic control, body weight, and lipid profile in adults with type 2 diabetes. Design Systematic review and network meta-analysis. Data sources PubMed, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase from database inception to 19 August 2023. Eligibility criteria for selecting studies Eligible randomised controlled trials enrolled adults with type 2 diabetes who received GLP-1RA treatments and compared effects with placebo or any GLP-1RA d...
Purpose-built data repositories are the most effective, stable, and discoverable way to share research data—which means more attention and impact for research.
Objectives To evaluate the long term risks of invasive breast cancer and death related to breast cancer after non-screen detected ductal carcinoma in situ. Risks for women in the general population and for women diagnosed with ductal carcinoma in situ via the screening programme were compared. Design Population based cohort study. Setting Data from the National Disease Registration Service. Participants All 27 543 women in England who were diagnosed with ductal carcinoma in situ, outside the NHS breast screening programme, during 1990 to 2018. Main outcome measures Incident invasive breast c...
Paige McDonald and colleagues detail key domains, tools, and actions required to enact learning health systems for continuous intelligent improvement in healthcare Despite an increased focus on quality improvement in healthcare over the past 50 years, many of the same problems persist. This disconnect has been described as the 60-30-10 challenge: only 60% of care, on average, aligns with evidence or consensus based guidelines; another 30% of care is waste or of low value; and 10% of patients experience adverse events.1 These statistics have persisted for over three decades.2 Even with technolo...