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Decades old water piping made from asbestos cement is starting to degrade – but what does it mean for human health?

Estimands can be used in studies of healthcare interventions to clarify the interpretation of treatment effects. The addendum to the ICH E9 harmonised guideline on statistical principles for clinical trials (ICH E9(R1)) describes a framework for using estimands as part of a study. This paper provides an overview of the estimands framework, as outlined in the addendum, with the aim of explaining why estimands are beneficial; clarifying the terminology being used; and providing practical guidance on using estimands to decide the appropriate study design, data collection, and estimation methods. ...

To remain on track in meeting the country’s goals by 2028, the National Economic and Development Authority (Neda) has urged Congress to pass bills that address the “structural weaknesses” of the country’s production sectors, among others. Neda said these measures include the bills on the Department of Water Resources, Open…

Angle PLC Announces Potential Utility in Precision Oncology

An external validation study evaluates the performance of a prediction model in new data, but many of these studies are too small to provide reliable answers. In the third article of their series on model evaluation, Riley and colleagues describe how to calculate the sample size required for external validation studies, and propose to avoid rules of thumb by tailoring calculations to the model and setting at hand. External validation studies evaluate the performance of one or more prediction models (eg, developed previously using statistical, machine learning, or artificial intelligence approa...