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"Multimodal Analgesic Effectiveness on Acute Postoperative Pain Managem" by Rochelle Wynne, Suzanne Fredericks et al.

Background Many patients report moderate to severe pain in the acute postoperative period. Enhanced recovery protocols recommend multimodal analgesics, but the optimal combination of these is unknown. Purpose The aim of this study was to synthesize the best available evidence about effectiveness of multimodal analgesics on pain after adult cardiac surgery. Methods A systematic review to determine the effect of multimodal postoperative analgesics is proposed (International Prospective Register of Systematic Reviews Registration CRD42022355834). Multiple databases including the Cochrane Library, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, American Psychological Association, the Education Resources Information Centre, the Excerpta Medica database, the Medical Literature Analysis and Retrieval System Online, Scopus, Web of Science, and clinical trials databases will be searched. Screening in Covidence and quality assessment will ....

United States , Cochrane Library , Education Resources Information Centre , American Psychological Association , International Prospective Register Of Systematic Reviews Registration , Health Literature , International Prospective Register , Systematic Reviews Registration , Cochrane Central Register , Controlled Trials , Cumulative Index , Allied Health Literature , Excerpta Medica , Medical Literature Analysis , Retrieval System Online , Cardiac Surgery , Ultimodal Analgesics , Pain Management ,

India, US agree to share more information to curb illegal opioid trade

The US and India discussed information sharing on the illegal trade of opioids, such as fentanyl, and countering terrorism. They focused on the rising threat from radicalized individuals and organized terror groups. China is also involved in countering narcotics. ....

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