Objective: Bacterial meningitis (BM) is a public health threat with considerable mortality and morbidity worldwide; particularly in the meningitis belt of Africa where Ethiopia is located. The study aims to assess the prevalence, antibiogram, and associated factors of bacteria isolated from presumptive meningitis patients at Debre Markos Comprehensive Specialized Hospital (DMCSH), Northwest Ethiopia.
Methods: We conducted a cross-sectional study between March 1, 2021, and May 30, 2021. Socio-demographic and clinical data were collected using structured questionnaires. Cerebrospinal fluid (CSF) was collected aseptically, and gram stain, culture, and biochemical tests were performed to identify bacterial isolates. An antimicrobial susceptibility test was conducted using the disc diffusion method on Mueller-Hinton agar (MHA). Data were entered into EpiData version 3.1 (Epidata Association, Denmark) and exported to SPSS version 23 software (IBM Corp., Armonk, NY) for analysis. P value
To determine bacteriological profiles, antimicrobial susceptibility patterns, & biofilm forming ability of isolates, as well as factors associated with OSSIs.
10 Another study noted that
E. coli were 90%, 16.7%, 10% and 13.3% resistant to trimethoprim-sulfamethoxazole, nitrofurantoin, gentamicin and ceftriaxone, respectively. The resistance rates for
K. pneumoniae were 72.7%, 33.3% and 0% for trimethoprim-sulfamethoxazole, nitrofurantoin and ceftriaxone respectively.
8 The prevalence of asymptomatic UTI and its resistance pattern in non-pregnant PLHIV in this context is not well known.
According to the Tanzanian standard treatment guideline of 2017, UTI in the general population is treated by ciprofloxacin with the exception of pregnant women and adolescents who are treated with amoxicillin-clavulanic acid. Referral to a high level of health facility is recommended for patients with acute pyelonephritis and the following characteristics: a) presence of vomiting, sepsis and known diabetes mellitus or b) pregnant women, women beyond reproductive age and in men. Before referral these patients receive ceftriaxone 50–80 mg/kg/dose as a
Acinetobacterbaumannii &
Pseudomonas species) and
Enterobacteriaceae-producing extended-spectrum β-lactamases and carbapenemases in severe healthcare-associated infections for the medical community in recent decades.
Healthcare-associated infections (HAIs) are associated with significant mortality, morbidity, and high economic burden and they are a major challenge to the healthcare system. The constant handling of mobile phones (MPs) by users in hospitals (patients, visitors, and healthcare workers, etc.) makes it a suitable place for transmission of multidrug-resistant bacteria (MDR), as well as healthcare-associated infections.
Mobile phones are widely used in healthcare facilities, even reaching operating rooms. It has been shown that mobile phones may serve as reservoir of MDR bacteria like ESBL, MRSA, and VRE and even they serve as a reservoir for viruses like COVID-19 which could easily be transmitted from MPs to the healthcare workers hands, therefore facilitating the t