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CN Bio introduces the PhysioMimix™ OOC Multi-Organ Microphysiological System


CN Bio introduces the PhysioMimix™ OOC Multi-Organ Microphysiological System
CN Bio, a leading developer of single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip (OOC), today announced the commercial launch of its new PhysioMimix™ OOC Multi-Organ MPS.
The next-generation platform combines CN Bio’s in vitro 3D liver model, whose phenotype and functions mimic that in vivo, with a range of other organs to more accurately recapitulate the multi-organ and systemic effects observed in humans. Demonstrating a key milestone in the Company’s mission to develop the most complete human ‘body-on-a-chip’ in the laboratory, the PhysioMimix OOC Multi-Organ MPS will provide advanced insights into the potential effects of novel therapeutics that were previously only achievable using animal models. ....

David Hughes , Tomasz Kostrzewski , Society Of Toxicology , Integrative Systems Biology Department , University Of Pittsburgh , Innovations Limitedmar , Physiologically Based Pharmacokinetics , Jalan Wells , Physiomimix Multi Organ , Annual Meeting , Microphysiological Systems , Physiomimix Single Organ , Physiomimix Multi Organ Systems , In Vitro , In Vivo , டேவிட் ஹக்ஸ் , சமூகம் ஆஃப் நச்சுயியல் , ஒருங்கிணைந்த அமைப்புகள் உயிரியல் துறை , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் , ஆலன் கிணறுகள் , ஆண்டு சந்தித்தல் , இல் விட்ரோ , இல் விவோ ,

RNA editing events influence gene expression and phenotypic manifestation


RNA editing events influence gene expression and phenotypic manifestation
Combining computational mining of big data with experimental testing in the lab, researchers at Children s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence gene expression and, in turn, the phenotypic manifestation of that expression.
In analyzing so-called A-to-I RNA editing, in which the adenosine of an RNA molecule is chemically modified into an inosine, the researchers describe how a single nucleotide change by RNA editing can have large downstream effects. The findings were published today in
Genome Biology.
Millions of A-to-I RNA editing sites have been identified across the human transcriptome, but the functions of most RNA editing events are unknown. Understanding how RNA editing affects gene expression and phenotype could help us unravel the genetic basis to many human conditions. ....

United States , Emily Henderson , Study Senior Author , Genomic Medicine , Tissue Expression , Gene Expression , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , படிப்பு மூத்தவர் நூலாசிரியர் , திசு வெளிப்பாடு , கீந் வெளிப்பாடு ,