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ACMG releases new Points to Consider statement on the clinical utility of polygenic risk scores for embryo selection

Should we be using polygenic risk score assessment for embryo selection? Providing in-depth analysis, the Social, Ethical and Legal Issues Committee of the American College of Medical Genetics and Genomics (ACMG) has released a new Points to Consider statement to assist healthcare professionals and patients in understanding the safety and utility of preimplantation genetic testing for polygenic disorders (PGT-P) as a clinical service.

Susan-klugman , Theresaa-grebe , American-college-of-medical-genetics , Medical-genetics , Legal-issues-committee , American-college , Polygenic-risk-scores , Embryo-selection , Consider-statement , Efficacy , Enetics , Enomics

ACMG Issues Statement on Safety of Genetic Embryo Selection

ACMG Issues Statement on Safety of Genetic Embryo Selection
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Theresaa-grebe , Susan-klugman , American-college-of-medical-genetics , Foundation-for-genetic , Legal-issues-committee , American-college , Medical-genetics , Polygenic-risk-scores , Embryo-selection , Consider-statement , Medicine-open , Genomic-medicine

Statement on safety and efficacy of polygenic risk score assessment for embryo selection: Points to consider

Statement on safety and efficacy of polygenic risk score assessment for embryo selection: Points to consider
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Theresaa-grebe , Susan-klugman , Legal-issues-committee , American-college , Medical-genetics , Polygenic-risk-scores , Embryo-selection , Consider-statement , Clinical-utility ,

All of Us: 413,000 genomes across ancestries, ages, socioeconomics

Since its founding by the National Institutes of Health (NIH), the scientists of the All of Us Research Program have set the goal to analyze the largest diversity of the genomic population in the country and end the under-representation of its different groups. The project has expanded the vision of several pathologies, discovered thousands of new genetic variants, redefined the risk genes for common diseases, and stratified them, uncovering eight different forms in the case of type 2 diabetes (T2D). Their results create a pathway for a new age of precision medicine.

National-institutes-of-health , Us-research-program , National-institutes , Bioworld-science , All-of-us , Underrepresented-population , Polygenic-risk-scores , Type-2-diabetes , Precision-medicine , Nih , Drug-design

'This innovation was a home run!': Top tech projects for 8 systems

'This innovation was a home run!': Top tech projects for 8 systems
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ASHG News: Improved Approach to Predicting the Risk of Coronary Artery Disease

ASHG News: Improved Approach to Predicting the Risk of Coronary Artery Disease
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Akash-kumar , South-asian , Atherosclerotic-cardiovascular-disease , Pooled-cohort-equation , Polygenic-risk-scores , Clinical-factors-improves , Risk-prediction , Coronary-artery-disease ,

MyOme Presents New Data: Improved 10-year Risk Prediction of Coronary Artery Disease through Polygenic Risk Scores Integrated with Clinical Factors Showcased at the American Society of Human Genetics

MyOme Presents New Data: Improved 10-year Risk Prediction of Coronary Artery Disease through Polygenic Risk Scores Integrated with Clinical Factors Showcased at the American Society of Human Genetics
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MyOme Presents New Data: Improved 10-year Risk Prediction of Coronary Artery Disease through Polygenic Risk Scores Integrated with Clinical Factors Showcased at the American Society of Human Genetics Annual Meeting

MyOme Presents New Data: Improved 10-year Risk Prediction of Coronary Artery Disease through Polygenic Risk Scores Integrated with Clinical Factors Showcased at the American Society of Human Genetics Annual Meeting
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MyOme Presents New Data: Improved 10-year Risk Prediction of Coronary Artery Disease through Polygenic Risk Scores Integrated with Clinical Factors Showcased at the American Society of Human Genetics Annual Meeting

MyOme Presents New Data: Improved 10-year Risk Prediction of Coronary Artery Disease through Polygenic Risk Scores Integrated with Clinical Factors Showcased at the American Society of Human Genetics Annual Meeting
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Genetic risk scores 'do not have a place in public health screening'

Researchers said the scoring system led to false positives and ‘performed poorly' when predicting if a person would develop common diseases.

United-kingdom , Cambridge , Cambridgeshire , London , City-of , British , Aroon-hingorani , Nick-wald , Michael-inouye , Sam-lambert , Jasmine-gratton , Nicholas-wald