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Scientists Might Know Why You Feel Loopy After an All-Nighter

Northwestern University scientists may have figured out why pulling an all-nighter can leave us feeling loopy and downright giddy for days after. In a new study out this week, the researchers found that acute sleep deprivation in mice can trigger a rapid release of dopamine within the brain and boost its plasticity, temporarily creating hyperactive and antidepressant effects. The findings might actually help scientists learn how to craft better treatments for mood disorders, the authors say. ....

Yevgenia Kozorovitskiy , Northwestern University , Mood Disorders , Yevgenia Kozorovitskiy , Prefrontal Cortex , Northwestern University , Antidepressant Effect , Brain Regions , Food Stability , Antidepressant Effects , Nucleus Accumbens , Sleep Deprivation ,

How deep is the brain? The shallow brain hypothesis | Nature Reviews Neuroscience

Deep learning and predictive coding architectures commonly assume that inference in neural networks is hierarchical. However, largely neglected in deep learning and predictive coding architectures is the neurobiological evidence that all hierarchical cortical areas, higher or lower, project to and receive signals directly from subcortical areas. Given these neuroanatomical facts, today’s dominance of cortico-centric, hierarchical architectures in deep learning and predictive coding networks is highly questionable; such architectures are likely to be missing essential computational principles the brain uses. In this Perspective, we present the shallow brain hypothesis: hierarchical cortical processing is integrated with a massively parallel process to which subcortical areas substantially contribute. This shallow architecture exploits the computational capacity of cortical microcircuits and thalamo-cortical loops that are not included in typical hierarchical deep learning ....

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