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Cone snail venom could potentially treat severe forms of malaria

Cone snail venom could potentially treat severe forms of malaria
Plasmodium falciparum may be deadly even after treatment with current parasite-killing drugs. This is due to persistent cyto-adhesion of infected erythrocytes even though existing parasites within the red blood cells are dead.
As vaccines for malaria have proved less than moderately effective, and to treat these severe cases of
P. falciparum malaria, new avenues are urgently needed. Latest estimates indicate that more than 500 million cases of malaria and more than 400,000 deaths are reported worldwide each year
. Anti-adhesion drugs may hold the key to significantly improving survival rates.
Using venom from the ....

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Analytical Chemistry of Beer and Brewing

NewsMed talks to Chris Welch about their Pittcon presentation on the analytical chemistry involved in beer brewing. ....

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Finding coronavirus's helper proteins

EMBL scientists identify human proteins hijacked by coronavirus, offering potential drug targets
EMBL scientists used a biophysical method called thermal proteome profiling (TPP) to gain a comprehensive overview of which human proteins are functionally altered at different times during SARS-CoV-2 infection. Credit: Holly Joynes/EMBL
A group of scientists led by EMBL’s Mikhail Savitski, Nassos Typas, and Pedro Beltrao, and collaborator Steeve Boulant at Heidelberg University Hospital, have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication.
The researchers used a biophysical method called thermal proteome profiling (TPP) to gain a comprehensive overview of which human proteins are functionally altered during SARS-CoV-2 infection. TPP monitors protein amounts and denaturation temperatures – the points at which proteins heat up so much that they lose their ....

Baden Wuberg , Holly Joynes , Mikhail Savitski , Nassos Typas , Pedro Beltrao , Technical University Of Munich , European Bioinformatics Institute , Steeve Boulant At Heidelberg University Hospital , Heidelberg University Hospital , German Cancer Research Center , Steeve Boulant , Genome Biology Unit , Core Facility , Bioinformatics Institute , Technical University , University Of Munich , Cancer Research , Corona Virus , ஹோலி ஜாய்ன்ஸ் , பேடரோ பெல்ட்ராவ் , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச் , ஐரோப்பிய உயிர் தகவலியல் நிறுவனம் , ஹைடெல்பெர்க் பல்கலைக்கழகம் மருத்துவமனை , ஜெர்மன் புற்றுநோய் ஆராய்ச்சி மையம் , மரபணு உயிரியல் அலகு , கோர் வசதி ,

BMI, male sex, smoking, depression and metabolic syndrome contribute to biological aging

BMI, male sex, smoking, depression and metabolic syndrome contribute to biological aging
A biological age score predicts that being male, overweight, a smoker and having depression all contribute to biological aging, a study published today in
eLife reports.
Aging can be measured in different ways. While chronological age is measured by date of birth, scientists have developed a range of measurements to determine our biological age. These include measuring the length of telomeres (little caps on the end of our chromosomes that shorten as we grow older), chemical changes to our DNA (epigenetics), and changes to the proteins and metabolites in our bodies (proteomic and metabolomic measures). ....

Noord Holland , Rick Jansen , Brenda Penninx , Emily Henderson , Department Of Psychiatry , Assistant Professor , Netherlands Study , Psychiatric Epidemiology , Cell Biology , Mental Health , Metabolic Syndrome , நூற்த் ஹாலண்ட் , ரிக் ஜான்சன் , எமிலி ஹென்டர்சன் , துறை ஆஃப் மனநல மருத்துவம் , உதவியாளர் ப்ரொஃபெஸர் , நெதர்லாந்து படிப்பு , மனநல தொற்றுநோய் , செல் உயிரியல் , மன ஆரோக்கியம் , வளர்சிதை மாற்ற நோய்க்குறி , மனநல மருத்துவம் ,

Nautilus Bio lines up SPAC merger and $350M in funding for proteomics R&D

MedCity News
Nautilus Bio lines up SPAC merger and $350M in funding for proteomics R&D
Nautilus, among the biotechs developing protein analysis tools for drug discovery and diagnostics, already has a partnership with Genentech. As it prepares to go public, Nautilus aims to do for proteomics what Illumina did for genomics.
Shares1

Nautilus Biotechnology is joining the public markets through a merger that provides it with $350 million to ramp up work developing its protein analysis technology for drug discovery and diagnostic applications.
Seattle-based Nautilus is combining with Arya III, a special purpose acquisition company (SPAC), which is a publicly traded entity formed as a vehicle for other companies to go public. The combined company, which will be run by Nautilus’s management, will have a valuation of about $900 million. When the deal closes, Nautilus expects that its shares will trade on the Nasdaq under the stock symbol “NAUT.” ....

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