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New method shows promise in identifying disease-fighting drug targets

Professor Ron Quinn AM, Principal Research Leader at the Griffith Institute for Drug Discovery.
A new method of identifying molecular targets to fight disease could help accelerate future drug development new Griffith University research published in Scientific Reports has found.
“Even in this molecular era of drug discovery, there remain new investigational drugs whose molecular targets are unclear, restricting their optimisation and broad use in disease,” Professor Quinn said.
Protein 4J57 – “Plasmodium falciparum thioredoxin reductase-thioredoxin complex”
“A key step in the discovery of new pharmaceutical drugs and developing them to useful treatments for patients is, therefore, the identification of the molecular target while, at the same time, ensuring the drug does not interact with other gene products that would cause side effects.” ....

Miaomiao Liu , Griffith University , Principal Research Leader , Griffith Institute For Drug Discovery , Professor Ron Quinn , Griffith Institute , Scientific Reports , Drug Discovery , Drug Development , கிரிஃபித் பல்கலைக்கழகம் , ப்ரிந்ஸிபல் ஆராய்ச்சி தலைவர் , கிரிஃபித் நிறுவனம் க்கு மருந்து கண்டுபிடிப்பு , ப்ரொஃபெஸர் ரோன் க்வின் , கிரிஃபித் நிறுவனம் , அறிவியல் அறிக்கைகள் , மருந்து கண்டுபிடிப்பு , மருந்து வளர்ச்சி ,

Researchers develop new method for charting SARS-CoV-2 spike protein glycosylation

Researchers develop new method for charting SARS-CoV-2 spike protein glycosylation
Researchers have developed a novel, simple and affordable method for N-glycan fingerprinting based on enzymatic fluorescent glycan labeling and electrophoresis. This new method may help us understand important changes in glycosylation in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein – something which could inform future therapeutic research.
Advances in genomics, proteomics and mass spectrometry have enabled scientists to identify specific glycans on proteins and their association with diseases. However, these methods are expensive, require highly trained experts to perform and are not easily available.
Researchers Zhengliang L. Wu and James M. Ertelt released the N-glycans present on a glycoprotein and labeled them enzymatically using fluorophore-conjugated sialic acid and fucose, and separated them using gel electrophoresis. The fingerprint of the gly ....

Ramya Dwivedi , Coronavirus Disease Covid 19 , Sars Cov 2 , Spike Protein , Corona Virus , Gel Electrophoresis , Mass Spectrometry , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ரம்யா டுவிவேடி , ஸ்பைக் ப்ரோடீந் , கொரோனா வைரஸ் , நிறை ஸ்பெக்ட்ரோமெட்ரி , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

National consortium to study threats of new SARS-CoV-2 variants

Date Time
National consortium to study threats of new SARS-CoV-2 variants
The University of Liverpool is part of a new national research project to study the effects of emerging mutations in SARS-CoV-2.
Supported by £2.5 million funding from UK Research and Innovation (UKRI), the ‘G2P-UK’ National Virology Consortium will study how mutations in the virus affect key outcomes such as how transmissible it is, the severity of COVID-19 it causes, and the effectiveness of vaccines and treatments.
The consortium will bring together leading virologists from 10 research institutions including the University of Liverpool. They will work alongside the COVID-19 Genomics UK (COG-UK) consortium, which plays a world-leading role in virus genome sequencing, and Public Health England to boost the UK’s capacity to study newly identified virus variants and rapidly inform government policy. ....

South Africa , United Kingdom , City Of , Julian Hiscox , Amanda Solloway , James Stewart , Wendy Barclay , Kingdom National Virology Consortium , United Kingdom Research , Imperial College London , Public Health England , Ecological Sciences , Institute Of Infection , University Of Liverpool , United Kingdom National Virology Consortium , Professor Wendy Barclay , Professor Julian Hiscox , Professor James Stewart , Minister Amanda Solloway , Government Policy , Public Health , Corona Virus , ஒன்றுபட்டது கிஂக்டம் , நகரம் ஆஃப் , ஜூலியன் ஹிஸ்காக்ஸ் , அமண்டா சொல்லொவாய் ,

Religious beliefs modulate protein expression linked to cardiovascular disease in US South Asians

Religious beliefs modulate protein expression linked to cardiovascular disease in US South Asians
The Study on Stress, Spirituality and Health (SSSH), a cutting-edge proteomics analysis, suggests that religious beliefs modulate protein expression associated with cardiovascular disease in South Asians in the United States. The research, published by investigators from Massachusetts General Hospital (MGH) and Beth Israel Deaconess Medical Center (BIDMC) and the University of California San Francisco (UCSF) in
Scientific Reports, demonstrates that spiritual struggles, in particular, significantly modify the impact of unique proteins on risk of developing cardiovascular disease (CVD) in U.S. South Asians, a community that has especially high rates of CVD. ....

United States , Towia Libermann , Emily Henderson , Medicine At Harvard Medical School , Center On Genomics , Beth Israel Deaconess Medical Center , Health Disparities , Systems Biology Center , Mongan Institute , University Of California San Francisco , South Asians , Massachusetts General Hospital , California San Francisco , Scientific Reports , Alexandra Shields , Vulnerable Populations , Harvard Medical School , South Asians Living , San Francisco Bay Area , General Medicine , Cardiovascular Disease , Medical School , Protein Expression , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , மருந்து இல் ஹார்வர்ட் மருத்துவ பள்ளி ,

Bruker and Evosep announce major progress in unbiased, quantitative true single-cell proteomics

Bruker and Evosep announce major progress in unbiased, quantitative true single-cell proteomics
Bruker Corporation and Evosep today announced major progress in high-sensitivity, quantitative true single-cell proteomics, using a modified
timsTOF Pro mass spectrometer connected to an
Evosep One low-flow chromatography system.
Evosep One is a chromatography system that delivers fast, sensitive and robust proteomic analysis of clinical samples, while supporting connections to a wide range of mass spectrometers.
These advances have been demonstrated by the Mann-group in a paper by
A. Brunner et al., which is now available on Bioarchive here. Key results include the first untargeted and unbiased analysis of true single cells achieving an identification depth of up to 1,500 protein groups from single FACS-sorted and individually digested HeLa cells. This remarkable sensitivity was achieved by the combined ....

Matthias Mann , Nicolai Bache , Gary Kruppa , Bruker Corporation , Max Planck Institute Of Biochemistry , Evosep One , Max Planck Institute , Vice President , Hela Cells , மத்தியாஸ் மான் , நிகோலாய் பச்செ , கேரி கிருப்பா , ப்ரூக்கர் நிறுவனம் , துணை ப்ரெஸிடெஂட் , ஹெலா செல்கள் ,