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欧冠-米利克破门米雷蒂送点 尤文1-2本菲卡小组赛遭两连败

欧冠-米利克破门米雷蒂送点 尤文1-2本菲卡小组赛遭两连败
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Germany , Austria , Russia , Sri-lanka , Soviet , Ramos-silva , Ang-mario , Raphael-silva , Bernard-hawthorn , Antonio-silva-bach , Europe-crown , Union-levin

Frontiers | Preexposure and Postexposure Prophylaxis of Rabies With Adeno-Associated Virus Expressing Virus-Neutralizing Antibody in Rodent Models

Rabies, a fatal disease in humans and other mammals, is caused by the rabies virus (RABV), and it poses a public health threat in many parts of the world. Once symptoms of rabies appear, the mortality is near 100%. There is currently no effective treatment for rabies. In our study, two human-derived RABV-neutralizing antibodies (RVNA), CR57 and CR4098, were cloned into adeno-associated virus (AAV) vectors, and recombinant AAVs expressing RVNA were evaluated for postexposure prophylaxis after intrathecal injection into RABV-infected rats. At 4 days post-infection with a lethal dose of RABV, 60% of the rats that received an intrathecal injection of AAV-CR57 survived, while 100% of the rats inoculated with AAV-EGFP succumbed to rabies. Overall, these results demonstrate that AAV-encoding RVNA can be utilized as a potential human rabies postexposure prophylaxis.

South-korea , Mexico , Huazhong , Hubei , China , Japan , Tokyo , United-states , Massachusetts , Guangdong , Wuhan , Gang-cao