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sudok1 / iStock A systematic review and meta-analysis of 10 randomized controlled studies concludes that use of convalescent plasma in COVID-19 patients doesn't appear to improve survival or clinical status, shorten hospital stays, or reduce the need for mechanical ventilation. Led by researchers at the University of Basel in Switzerland and published late last week in JAMA, the study found that the risk ratio (RR) for death in the four peer-reviewed, published trials involving 1,060 coronavirus patients was 0.93 (95% confidence interval [CI], 0.63 to 1.38; absolute risk difference, -1.21% (...

Three of the trials did not have study acronyms (only trial registration numbers) and ILBS-COVID-02 and PLACID did not have expansions in the original publications. ConCOVID indicates Convalescent Plasma as Therapy for Covid-19 Severe SARS-CoV-2 Disease; ConPlas-19, Convalescent Plasma Therapy vs SOC for the Treatment of COVID-19 in Hospitalized Patients; NA, not available; PICP19, Passive Immunization With Convalescent Plasma in Severe COVID-19 Disease; PlasmAr, Convalescent Plasma and Placebo for the Treatment of COVID-19 Severe Pneumonia; RECOVERY, Randomized Evaluation of COVID-19 Therapy...

Perrine Janiaud, PhD; Cathrine Axfors, MD, PhD; Andreas M. Schmitt, MD; Viktoria Gloy, PhD; Fahim Ebrahimi, MD, MSc; Matthias Hepprich, MD; Emily R. Smith, ScD, MPH; Noah A. Haber, ScD; Nina Khanna, MD; David Moher, PhD; Steven N. Goodman, MD, PhD; John P. A. Ioannidis, MD, DSc; Lars G. Hemkens, MD, MPH In this issue of JAMA, Janiaud et al 1 present a meta-analysis of randomized clinical trials (RCTs) of convalescent plasma for the treatment of patients with COVID-19. Based on an analysis of 1060 patients from 4 RCTs published in peer-reviewed journals and 10 722 ...

A To assess the safety and effectiveness of their Covid-19 vaccines, BioNTech SE, Pfizer Inc. and Moderna Inc. sponsored clinical trials overseen by independent boards that recruited tens of thousands of participants, randomly assigned them to receive vaccines or placebos and waited to see if there was a discernible difference in outcomes between the two groups. With the rapid spread of the new coronavirus in the US this fall, they didn’t have to wait long — and the results were stunning. In both trials, about 95% of those who developed Covid symptoms were in the placebo group, meani...