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CGT Catapult appoints new Non-Executive Directors

CGT Catapult appoints new Non-Executive Directors
europeanpharmaceuticalreview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from europeanpharmaceuticalreview.com Daily Mail and Mail on Sunday newspapers.

United-kingdom , Ireland , Bristol , City-of , Nicole-mather , Ian-mccubbin , Jim-faulkner , Carolyn-porter , Glaxosmithkline , Office-for-life-sciences , Autolus-ltd , Oxford-university

Identification of patients undergoing chronic kidney replacement therapy in primary and secondary care data: validation study based on OpenSAFELY and UK Renal Registry

Identification of patients undergoing chronic kidney replacement therapy in primary and secondary care data: validation study based on OpenSAFELY and UK Renal Registry
bmj.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bmj.com Daily Mail and Mail on Sunday newspapers.

United-kingdom , Phoenix , Arizona , United-states , Nitin-kolhe , Health-research-authority , Health-research-authority-confidentiality-advisory-group , London-school-of-hygiene , Health-service-control-of-patient-information-regulations , Phoenix-partnership , Massachusetts-institute-of-technology , Digital-secondary-uses-services

Adult transgender clinics in England face inquiry into patient care

NHS England to review seven specialist services after staff share misgivings privately

United-kingdom , Tavistock , Devon , John-stewart , Kate-barker , Hilary-cass , James-palmer , David-bell , Devon-partnership , University-of-york , Royal-college-of-paediatrics , Health-research-authority

Diagnosis and management of endometrial hyperplasia: A UK national audit of adherence to national guidance 2012–2020

Author summary Why was this study done? New national guidance was introduced in the United Kingdom with recommendations for the care and surveillance of people with endometrial hyperplasia (EH). Comparing patterns of care with these recommendations has identified opportunities for improvement. What did the researchers do and find? After the guidance, medical treatment of non-atypical hyperplasia increased and more patients achieved histological regression, avoiding hysterectomy. Surveillance of hyperplasia for those who do not undergo hysterectomy could be improved. A greater proportion of women with atypia diagnosed in 2020 commenced medical management and fewer underwent hysterectomy; the impact of the pandemic on care must be considered as a contributory factor towards this. What do these findings mean? This work has identified where the care of patients with EH diverged from recommended guidance. Clinicians may use these findings to review their local care pathways and quality assurance processes so that they can improve the care of women with EH. The main limitation was the retrospective collection of data from routine clinical documentation.

United-kingdom , Green-top , Texas , United-states , Edinburgh , City-of , Netherlands , Canada , British , Dutch , Royal-college-of-obstetricians

The Ghost Research Haunting Nordic Medical Trials

The results of hundreds of clinical trials in Nordic countries have never been made public. Experts say it's a global problem.

Germany , Sweden , Iceland , Finland , Helsinki , Eteläuomen-läi , Norway , Denmark , United-states , United-kingdom , American , German

Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial

Objective To evaluate whether a structured online supervised group physical and mental health rehabilitation programme can improve health related quality of life compared with usual care in adults with post-covid-19 condition (long covid).

Design Pragmatic, multicentre, parallel group, superiority randomised controlled trial.

Setting England and Wales, with home based interventions delivered remotely online from a single trial hub.

Participants 585 adults (26-86 years) discharged from NHS hospitals at least three months previously after covid-19 and with ongoing physical and/or mental health sequelae (post-covid-19 condition), randomised (1:1.03) to receive the Rehabilitation Exercise and psycholoGical support After covid-19 InfectioN (REGAIN) intervention (n=298) or usual care (n=287).

Interventions Best practice usual care was a single online session of advice and support with a trained practitioner. The REGAIN intervention was delivered online over eight weeks and consisted of weekly home based, live, supervised, group exercise and psychological support sessions.

Main outcome measures The primary outcome was health related quality of life using the patient reported outcomes measurement information system (PROMIS) preference (PROPr) score at three months. Secondary outcomes, measured at three, six, and 12 months, included PROMIS subscores (depression, fatigue, sleep disturbance, pain interference, physical function, social roles/activities, and cognitive function), severity of post-traumatic stress disorder, general health, and adverse events.

Results Between January 2021 and July 2022, 39 697 people were invited to take part in the study and 725 were contacted and eligible. 585 participants were randomised. Mean age was 56 (standard deviation (SD) 12) years, 52% were female participants, mean health related quality of life PROMIS-PROPr score was 0.20 (SD 0.17), and mean time from hospital discharge was 323 (SD 144) days. Compared with usual care, the REGAIN intervention led to improvements in health related quality of life (adjusted mean difference in PROPr score 0.03 (95% confidence interval 0.01 to 0.05), P=0.02) at three months, driven predominantly by greater improvements in the PROMIS subscores for depression (1.39 (0.06 to 2.71), P=0.04), fatigue (2.50 (1.19 to 3.81), P<0.001), and pain interference (1.80 (0.50 to 3.11), P=0.01). Effects were sustained at 12 months (0.03 (0.01 to 0.06), P=0.02). Of 21 serious adverse events, only one was possibly related to the REGAIN intervention. In the intervention group, 141 (47%) participants fully adhered to the programme, 117 (39%) partially adhered, and 40 (13%) did not receive the intervention.

Conclusions In adults with post-covid-19 condition, an online, home based, supervised, group physical and mental health rehabilitation programme was clinically effective at improving health related quality of life at three and 12 months compared with usual care.

Trial registration ISRCTN registry [ISRCTN11466448.][1]

Data are available on reasonable request from wctudataaccess@warwick.ac.uk.

[1]: /external-ref?link_type=ISRCTN&access_num=ISRCTN11466448.

Australia , United-kingdom , Cambridge , Cambridgeshire , Norway , Warwickshire , Norwegian , Australian , Scott-mcguire , David-mcwilliams , Helen-atherton , Jonathon-prosser

Mental health in the COVID-19 pandemic: A longitudinal analysis of the CLoCk cohort study

Laura Panagi and co-workers study mental health among children and young people in England during the COVID-19 pandemic.

South-yorkshire , United-kingdom-general- , United-kingdom , Cambridge , Cambridgeshire , United-states , British , Olivia-swann , Vikram-patel , Michael-lattimore , Elizabeth-whittaker , Department-of-health

Awakn Life Sciences Enters Into Global Licensing Agreement For Sublingual Delivery Formulation - Awakn Life Sciences (OTC:AWKNF)

Awakn Life Sciences&nbsp;(OTC: AWKNF), a clinical-stage biotechnology company specializing in the development of ketamine-assisted treatments for addiction, has&nbsp;enter

United-kingdom , Andernach , Rheinland-pfalz , Germany , Japan , China , Canada , Awakn-life-sciences-already-engaged-in-late , Sublingual-transdermal-administration-offers-therapeutic , Health-research-authority , Regulatory-agency

Tribulations and Trials

Tribulations and Trials
bmj.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bmj.com Daily Mail and Mail on Sunday newspapers.

United-kingdom , Health-research-authority , Information-act , Research-authority , Ethical-committees ,

Awakn Life Sciences Provides Corporate Update

Awakn Life Sciences Corp.  , a clinical-stage biotechnology company developing therapeutics to treat addiction with a near-term focus on Alcohol Use Disorder , shares a corporate update on recent...

United-states , Toronto , Ontario , Canada , Spain , France , Italy , Germany , United-kingdom , Anthony-tennyson , Catalent-zydis , Gordo-whittaker