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South Africa SARS-CoV-2 variant B.1.351 easily escapes Sputnik vaccine


South Africa SARS-CoV-2 variant B.1.351 easily escapes Sputnik vaccine
The current pandemic of novel coronavirus disease 2019 (COVID-19) was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has undergone numerous mutations in its genome to emerge as different variants. As of now, a dozen vaccines have received emergency use authorization, and many countries around the world have initiated mass vaccination campaigns.
A new preprint research paper posted to the
medRxiv server reports on vaccine resistance data that pushes the end of the pandemic further away.
Variants of concern and spike mutations
Most vaccines now in use or being developed focus on generating antibodies to the viral spike protein, which mediates host cell entry and infection. This is based on the strong correlation between neutralizing antibodies to the spike and protective immunity. ....

South Africa , United States , United Kingdom , South African , Liji Thomas , Astrazeneca Chadox , Bright Panel , South American , South America , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , சரி குழு , தெற்கு அமெரிக்கன் , தெற்கு அமெரிக்கா , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response


CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response
The effect of different neutralizing antibodies, both vaccine-elicited and from convalescent sera, suggests new variants are emerging that can evade the human immune response.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to host cells via its spike protein, which has two parts, the S1 and S2 subunits. The S1 subunit has the receptor-binding domain (RBD) and the N-terminal domain (NTD). The RBD binds to the host angiotensin-converting enzyme 2 (ACE2) to infect host cells.
Neutralizing antibodies are produced against both the RBD and NTD by infected and vaccinated individuals. Some RBD-specific monoclonal antibodies are currently under clinical trials or approved for use to treat COVID-19 patients. ....

United States , Lakshmi Supriya , United States Centers For Disease Control , Phd Apr , United States Centers , Disease Control , Immune Response , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , லட்சுமி சுப்ரியா , ஒன்றுபட்டது மாநிலங்களில் மையங்கள் க்கு நோய் கட்டுப்பாடு , ஃப்ட் ஏப்ரல் , ஒன்றுபட்டது மாநிலங்களில் மையங்கள் , நோய் கட்டுப்பாடு , நோய் எதிர்ப்பு சக்தி பதில் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?


Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?
The extent of severity of the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), varies from asymptomatic, mild to severe. Scientists found that during the first wave of the pandemic, individuals infected with non-severe SARS-CoV-2, before the onset of the vaccination program, induced effective host-defense mechanisms in naive populations.
To date, little evidence has been documented regarding the immune responses after the onset of the symptoms or virus detection. Further, no cross-sectional studies have been conducted that define the time of infection. Thereby, no report is available that explains the relationship between the earliest immune responses to COVID-19 and temporal kinetics. Scientists believe that understanding the early immune response regarding the asymptomatic or mildly infected population may help determine the factors ....

City Of , United Kingdom , Priyom Bose , Kateryna Kon Shutterstock , Kateryna Kon , Cell Proliferation , Corona Virus , Coronavirus Disease Covid 19 , Sars Cov 2 , Flow Cytometry , Immune Response , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , பிரீயோம் போஸ் , கொரோனா வைரஸ் , ஓட்டம் சைட்டோமெட்ரி , நோய் எதிர்ப்பு சக்தி பதில் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Researchers identify a novel SARS-CoV-2 variant (A.VOI.V2) in southern Africa


Researchers identify a novel SARS-CoV-2 variant (A.VOI.V2) in southern Africa
A team of international scientists has recently explored the transmission dynamics of currently circulating variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a southern African country. By analyzing the genomic sequences of these variants, they have identified a novel SARS-CoV-2 variant with multiple spike mutations. They have temporarily designated the variant A.VOI.V2. A detailed description of the genomic surveillance they carried out is currently available on the
Background
Since its emergence in December 2019, SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), has undergone more than 12,000 mutations. The majority of these mutations are found in the viral spike protein, which is a glycoprotein on the viral envelope required for establishing SARS-CoV-2 infection. Because of robust immunogenicity, the spike protein is considered to be the ....

South Africa , United Kingdom , South African , Sanchari Sinha Dutta , Network For Genomic Surveillance , African Society Of Laboratory Medicine , Africa Centers For Disease , Image Credit , Genomic Surveillance , Africa Centers , Disease Control , African Society , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , சஞ்சரி சீன்ஹா தத்தா , படம் கடன் , நோய் கட்டுப்பாடு , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks


New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks
In a methodologically ‘state-of-the-art’ approach, US researchers have developed a protein-based nanoparticle vaccine against coronavirus disease (COVID-19), with a swift generation of antibodies and the potential to protect individuals who cannot receive other COVID-19 vaccines for medical reasons. The research is posted to the
bioRxiv preprint server.
Vaccines currently in use against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of COVID-19, focus on the viral spike glycoprotein that mediates cell entry by targeting angiotensin receptor 2 (ACE2) as the main receptor and heparin as the co-receptor. ....

United States , Maggie Gu , Revacc Scientific , Image Credit , Sigma Adjuvant System , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Immune Response , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , மாகி கு , படம் கடன் , நானோ துகள்கள் , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,