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The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants
A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Their results are currently available on the
bioRxiv preprint server.
SARS-CoV-2, the causative agent of the ongoing coronavirus disease (COVID-19), uses its spike glycoprotein to interact with angiotensin-converting enzyme 2 (ACE2) in order to fuse cell membrane and viral envelope. The key determinant of host tropism is the S1 subunit of the spike glycoprotein, composed of the receptor-binding domain (RBD) and N-terminal domain (NTD). ....

United States , South Africa , United Kingdom , South African , Kamyab Javanmardi , University Of Texas At Austin , Golden Gate , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Cell Membrane , Corona Virus , Immune Response , Polyclonal Antibody , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் இல் ஆஸ்டின் , தங்கம் வாயில் , பிணைப்பு இன உறவு , செல் சவ்வு , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச ,

New software package employs deep-learning algorithms to analyze T-cell receptor sequencing data

New software package employs deep-learning algorithms to analyze T-cell receptor sequencing data
Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center have developed DeepTCR, a software package that employs deep-learning algorithms to analyze T-cell receptor (TCR) sequencing data. T-cell receptors are found on the surface of immune T cells. These receptors bind to certain antigens, or proteins, found on abnormal cells, such as cancer cells and cells infected with a virus or bacteria, to guide the T cells to attack and destroy the affected cells.
DeepTCR is an open-source software that can be used to answer questions in research into infectious disease, cancer immunology and autoimmune disease; any place where the immune system has a role through its T-cell receptors, said lead study author John-William Sidhom, an M.D./Ph.D. student at the Johns Hopkins University School of Medicine and Department of Biomedical En ....

United States , John William Sidhom , Emily Henderson , Nature Communications , American Association For Cancer Research , Johns Hopkins Kimmel Cancer Center , Bloomberg Kimmel Institute For Cancer Immunotherapy , Department Of Biomedical Engineering , Johns Hopkins University School Of Medicine , Kimmel Institute , Johns Hopkins University School , Biomedical Engineering , American Association , William Sidhom , Lead Study , Autoimmune Disease , Deep Learning , Immune Response , Immune System , T Cell , ஒன்றுபட்டது மாநிலங்களில் , ஜான் வில்லியம் சீதோம் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , ஜான்ஸ் ஹாப்கின்ஸ் கீம்மேல் புற்றுநோய் மையம் ,

Scientists use a novel two-step method to track receptor proteins

Scientists use a novel two-step method to track receptor proteins
The neurons in our nervous system talk to each other by sending and receiving chemical messages called neurotransmitters. This communication is facilitated by cell membrane proteins called receptors, which pick up neurotransmitters and relay them across cells. In a recent study published in
Nature Communications, scientists from Japan report their findings on the dynamics of receptors, which can enable understanding of the processes of memory formation and learning.
The regulation of receptor movement and localization within the neuron is important for synaptic plasticity, an important process in the central nervous system. A specific type of glutamate receptor, known as AMPA-type glutamate receptor (AMPAR), undergoes a constant cycle of trafficking , being cycled in and out of the neuronal membrane. A precise regulation of this trafficking process is associated with learning, memory formation, an ....

Shigeki Kiyonaka , Emily Henderson , Nature Communications , Nagoya University , Kyoto University , Keio University , Professor Shigeki Kiyonaka , Cell Membrane , Central Nervous System , Nervous System , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , நாகோயா பல்கலைக்கழகம் , கியோட்டோ பல்கலைக்கழகம் , கேோ பல்கலைக்கழகம் , செல் சவ்வு , மைய பதட்டமாக அமைப்பு , பதட்டமாக அமைப்பு ,

Treatment resistance in triple-negative breast cancers linked to softer tissue environment

Treatment resistance in triple-negative breast cancers linked to softer tissue environment
Researchers at the University of California, San Francisco, have discovered that aggressive, triple-negative breast cancers (TNBCs) can evade treatment by reorganizing and softening the collagen matrix that surrounds the cancer cells. The study, which will be published April 2 in the
Journal of Experimental Medicine (
JEM), shows that the softer matrix activates a signaling pathway that promotes the cancer cells survival, and suggests that targeting this pathway could enhance the effectiveness of chemo- and radiotherapy in TNBC patients.
TNBC is an aggressive type of breast cancer with worse survival rates than other forms of the disease. Because TNBC cells lack the HER2 signaling receptor and the estrogen and progesterone hormone receptors, they cannot be eliminated by drugs that specifically target these proteins. Instead, TNBC patients are normally treated with a combina ....

United States , San Francisco , Emily Henderson , University Of California , Department Of Radiation Oncology , Department Of Surgery , Experimental Medicine , Tissue Regeneration , Radiation Oncology , Breast Cancer , Signaling Pathway , ஒன்றுபட்டது மாநிலங்களில் , சான் பிரான்சிஸ்கோ , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , துறை ஆஃப் கதிர்வீச்சு புற்றுநோயியல் , துறை ஆஃப் அறுவை சிகிச்சை , சோதனை மருந்து , திசு மீளுருவாக்கம் , கதிர்வீச்சு புற்றுநோயியல் , மார்பக புற்றுநோய் , சமிக்ஞை நடைபாதை , மன அழுத்தம் , அறுவை சிகிச்சை ,

Temperature difference in the upper and lower respiratory tract influences SARS-CoV-2 replication

A team of researchers from the Institute for Infectious Diseases (IFIK) at the University of Bern and the Federal Institute of Virology and Immunology (IVI) have assessed virus growth and activation of the cellular defense mechanisms in the respiratory tract. ....

Ronald Dijkman , Emily Henderson , Institute For Infectious Diseases , Institute Of Virology , Swiss Institute For Translational Medicine , University Of Bern , Infectious Diseases , Federal Institute , Swiss Institute , Translational Medicine , Sars Cov 2 , Corona Virus , Immune Response , Immune System , எமிலி ஹென்டர்சன் , நிறுவனம் க்கு தொற்று நோய்கள் , நிறுவனம் ஆஃப் வைராலஜி , சுவிஸ் நிறுவனம் க்கு மொழிபெயர்ப்பு மருந்து , பல்கலைக்கழகம் ஆஃப் பெர்ன் , தொற்று நோய்கள் , கூட்டாட்சியின் நிறுவனம் , சுவிஸ் நிறுவனம் , மொழிபெயர்ப்பு மருந்து , கொரோனா வைரஸ் , நீரிழிவு நோய் , நோய் எதிர்ப்பு சக்தி பதில் ,