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Infertile men more likely to have impaired kidney function, study says

Study reveals that childless men are more likely to have decreased renal function and proteinuria than fathers, suggesting an association between male infertility and higher risks of kidney disease.

Sweden , Swedish , Swedish-tax-agency-statistics , Scientific-reports , Image-credit , Preventive-project , Kidney , Hronic , Reatinine , Ertility , Nfertility

"Urine congophilia associated with preeclampsia does not persist 6-mont" by P. Hofstee, J. S. Lum et al.

Introduction: Preeclampsia is a common hypertensive disorder of pregnancy. Several studies have demonstrated that protein aggregates, detected through urine congophilia, is associated with preeclampsia; however, it has yet to be investigated whether urine congophilia remains postpartum in these women. In this study, we aimed to augment prior studies and determine whether urine congophilia is present postpartum. Methods: Women were recruited from Lyell McEwin Hospital, South Australia. Urine samples were collected during pregnancy and 6-months postpartum from women with non-preeclampsia pregnancies (n = 48) and women with pregnancies complicated by preeclampsia (n = 42). A Congo Red Dot blot test, total protein and creatinine levels from urine, as well as serum Soluble fms-like tyrosine kinase 1 to placental growth factor ratio (sFlt-1:PlGF), were assessed and correlated. Results: Preeclamptic women exhibited increased urine congophilia (P < 0.01), sFlt-1:PlGF ratio (P < 0.0001) and total protein (P < 0.01) during pregnancy; with a positive correlation between urine congophilia and total protein across the entire cohort (P < 0.0001). Although urine congophilia was no longer detected 6-months postpartum in preeclamptic women, total protein remained elevated (P < 0.05). sFlt-1:PlGF ratio during pregnancy was positively correlated with congophilia across the cohort (P = 0.0007). Serum creatinine was also higher in preeclamptic women during pregnancy (P < 0.001). Discussion: These results support that urine congophilia is significantly elevated in pregnancies complicated with preeclampsia and show that it does not continue postpartum, although larger cohort studies are needed to determine its feasibility as a diagnostic marker.

Australia , Congo , Lyell-mcewin-hospital , Congo-red-dot , Congo-red , Bstetrics , Lacenta-amyloid , Regnancy , Rotein-aggregates , Roteinuria ,

Novartis reports success in phase 3 trial of drug for rare kidney disease

Novartis reports positive topline results from a Phase 3 trial of iptacopan, a drug to treat a rare kidney disease, C3 glomerulopathy.

Shreeram-aradhye , Novartis , Ptacopan , Abhalta , 3-glomerulopathy , Roteinuria , Idney-disease , Opline-results , Hase-3-trial , Da-approval , Are

High-impact clinical trial results to be presented at ASN Kidney Week 2023

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2023 November 1–November 5.

Tokyo , Japan , Groningen , Netherlands , France , Monaco , Canada , Brad-rovin , Michelle-rheault , Danielle-ellis , Hiddo-lambers-heerspink , Patrick-rossignol

Sparsentan may be a new treatment option for focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a rare kidney disorder that affects children and adults, and can lead to kidney failure.

Michelle-rheault , Megan-craig , M-health-fairview , University-of-minnesota-medical-school , M-medical-school , Minnesota-medical-school , New-england-journal , Kidney , Edical-school , Esearch , Hildren , Linical-trial

Coffee and genetics: A complex blend impacting kidney health

Researchers dive into the intricate connection between caffeine consumption and genetic predisposition, uncovering paradoxical effects on kidney function.

Neha-mathur , Neha-mathuroct , Aleksey-korchemkin-shutterstock , Sophia-coveney , Ckdgen-consortium , Caffeine-intake , Plasma-caffeine-level , Kidney-function , Mendelian-randomization , Image-credit , Caffeine , Enetic

Study supports vaccination for COVID-19 in patients with glomerular diseases

Among 2,055 adults with a wide range of glomerular diseases, the COVID-19 vaccination did not adversely affect kidney function or worsen kidney damage and appeared safe in this population.

United-states , American , Danielle-ellis , American-journal , Kidney-diseases , Covid-19 , Idney , Ephropathy , Roteinuria , Accine ,

Machine learning-based preeclampsia risk prediction

Study developed a machine-learning-based model using the Medical Record Longitudinal Information AI System (MERLIN).

Yuriyk-shutterstock , American-college-of-obstetricians , Medical-record-longitudinal-information , Image-credit , New-england , American-college , Machine-learning , Spirin , Lood , Lood-pressure , Dema , Aboratory

Travere Therapeutics, Inc. (NASDAQ:TVTX) Q2 2023 Earnings Call Transcript

Travere Therapeutics, Inc. (NASDAQ:TVTX) Q2 2023 Earnings Call Transcript August 4, 2023 Operator: Good day, and welcome to the Travere Therapeutics Second Quarter 2023 Financial Results and Corporate Update Conference Call. Today’s conference call is being recorded. At this time, I would like to turn the conference call over to the Vice President of Investor […]

Chris-cline , Travere-totalcare , Peter-heerma , Eric-dube , Naomi-eichenbaum , Romaset-shutterstock , Mirum-pharmaceuticals , World-ranked , Highest-rate , Travere-therapeutics , Ric-dube

The relationships between risk factors and kidney events in two diabetic cohorts

Researchers use the association rule to assess chronic kidney disease risk in the General and Worker diabetes populations.

Japan , Japanese , Scientific-reports , Improving-global-outcomes , Ishikawa-prefecture , Chronic , Hronic-kidney-disease , Idney , Idney-disease , Lbuminuria , Lood