The use of concentrated ionic liquids (ILs) in the bioanalytical chemistry of proteins is sparse; typically, dilute aqueous IL solutions are used. Concentrated ILs have unique properties that may allow researchers to dissolve previously insoluble protein analytes, to increase the depth and robustness of sample preparation and the analysis of proteins. Previous research using concentrated ILs for this purpose is sparse and there is a need to systematically investigate the structure-activity relationship between the IL structure and its capacity to solubilise proteins. Here, bovine serum albumin was dissolved in various ionic liquids and monitored over time by light microscopy and SDS-PAGE. While qualitative, these measures provide a good estimate of, respectively, the dissolving power of an IL towards the given protein and the retained integrity of the protein. Hydrophilic ILs show the best solubilisation capacity and higher temperatures (in a restricted sense) improve the solubility of the protein. Higher temperatures and longer reaction times reduce the molecular weight of the protein, which could inhibit their applicability in proteomics, unless the conditions are judiciously controlled. Researchers should exercise caution when using concentrated ILs for protein analysis until the full scope and limitations are known, an aspect we are presently investigating.
SRV Media Bangalore (Karnataka) [India], November 8: Vizzhy Inc, a leading Indian company, is propelling a healthcare revolution by channeling the potent combination of Multi-omics and Generative AI to tackle the root causes of metabolic diseases. With a commitment to invest USD 12.5 million in an American university, the company is set to explore novel avenues in the management of metabolic diseases. Vizzhy Inc Introduces Healthcare Transformation with Multi-omics and Generative AI Sreenivasulu AI for Wellness Center to Lead Pioneering Research on Metabolic Diseases A memorandum of understanding (MoU) between the University of Illinois Urbana-Champaign, a prestigious institution known for its Grainger Engineering School, and Vizzhy Inc, was formally signed at an event held in Bangalore. Speaking at the occasion, the Minister for Youth Empowerment, Sports, and Tribal Welfare B. Nagendra emphasized the importance of research as the cornerstone of addressing various societal challenges. The government of Karnataka is placing significant emphasis on research and development with the establishment of the Karnataka Research Foundation, and it welcomes investments from companies like Vizzhy Inc in the R&D sector with full government support. The Founder and CEO of Vizzhy Inc Dr. Vishnuvardhan noted that startling findings from the 2019 NHANES survey, which revealed that 88% of adults are metabolically unfit and that the average adult has gained 15kg since the 1970s, have prompted the company to redefine the healthcare landscape. This surge in metabolic diseases has propelled annual healthcare spending in the US to over USD 4 trillion, surpassing India's GDP. Vizzhy's approach focuses on a systems biology paradigm, emphasizing the five Ps: Preventative, Predictive, Precise, Participatory, and Personalized healthcare. The synergy of Multi-omics and Generative AI is at the heart of their strategy, addressing the fundamental causes of metabolic diseases. Multi-omics involves a comprehensive analysis of biological data, integrating genomics, proteomics, transcriptomics, and metabolomics to unravel intricate disease mechanisms and advance personalized medicine. Simultaneously, Vizzhy's application of Generative AI generates innovative medical data, expanding the possibilities for research and treatment. These technologies thrive on global collaboration, aggregating original research, expertise, datasets, and computational capabilities. In pursuit of this global effort, Vizzhy is proud to announce a USD 12.5 million funding for the Sreenivasulu AI for Wellness Center at the esteemed University of Illinois Urbana-Champaign, a top-ranking Grainger Engineering School. This center will assemble a team of distinguished scientists, engineers, and health system experts committed to addressing one of humanity's most pressing challenges. The center will be led by the renowned Prof. Narendra Ahuja, a top global scientist in Computer Vision, known for establishing India's first IIIT in Hyderabad. Vizzhy has already initiated numerous collaborative projects with eminent Indian institutions, such as IIT Bombay, and is expanding its university partnerships. This milestone achievement will not only serve Indian healthcare but also provide valuable datasets crucial for enhancing global health understanding and increasing life expectancy, he added. Chancellor of the University of Illinois Urbana-Champaign (USA) Prof. Roberty J. Jones Dean of the Grainger College of Engineering Prof. Rashid Bashir, Research Professor at University of Illinois Urbana-Champaign (USA) Prof. Narendra Ahuja, Professor-in-Charge, Koita Centre for Digital Health, IIT Bombay Prof. Ganesh Ramakrishna, Managing Director, Livlife Hospitals, Clinical Director and Chief Surgeon, KIMS Dr. Nandakishore Dukkipati were present on the occasion. Vizzhy Inc stands at the forefront of healthcare innovation, leveraging cutting-edge Multi-omics and Generative AI to create comprehensive solutions for the healthcare industry. Committed to the five Ps of healthcare and fostering international collaboration, Vizzhy is dedicated to enhancing both the lifespan and health span of populations worldwide. (ADVERTORIAL DISCLAIMER: The above press release has been provided by SRV Media. ANI will not be responsible in any way for the content of the same)
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