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Researchers test effects of full doses of anticoagulants in COVID-19 patients


Researchers test effects of full doses of anticoagulants in COVID-19 patients
Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients.
Among critically ill COVID-19 patients requiring intensive care unit (ICU) support, full-dose anticoagulation drugs did not improve outcomes. Enrollment continues for moderately ill hospitalized COVID-19 patients in the trials.
As is normal for clinical trials, these trials are overseen by independent boards that routinely review the data and are composed of experts in ethics, biostatistics, clinical trials, and blood clotting disorders. Informed by the deliberations of these oversight boards, all of the trial sites have paused enrollment of the most critically ill hospitalized patients with COVID-19. ....

Ryan Zarychanski , Ewan Goligher , Emily Henderson , University Of Toronto , Hospital Research Institute , University Health Network , Adaptive Platform Trial For Community , University Of Manitoba , Cancercare Manitoba , Multi Factorial Adaptive Platform Trial , Community Acquired Pneumonia , Therapeutic Anticoagulation , Antithrombotics Inpatient , Antithrombotic Therapy , Ameliorate Complications , Assistant Professor , Toronto General Hospital Research Institute , Critical Care , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , மருத்துவமனை ஆராய்ச்சி நிறுவனம் , பல்கலைக்கழகம் ஆரோக்கியம் வலைப்பின்னல் , மாற்றி அமைக்கத்தக்க நடைமேடை சோதனை க்கு சமூக , பல்கலைக்கழகம் ஆஃப் ம்யாநிடோப , புற்றுநோய் ம்யாநிடோப , சமூக வாங்கியது நூமோநிய ,

U of M pauses clinical trial of blood thinner for treating some COVID-19 patients


 
WINNIPEG
The University of Manitoba is pausing a clinical trial examining the use of blood thinners to help treat certain patients with COVID-19
The announcement was made in a news release on Tuesday, and affects critically ill patients who were in the ICU. The trial is part of three clinical trial platforms testing the effects of full doses of blood thinners in COVID-19 patients.
The trials were launched as clinicians noticed that many COVID-19 patients, including those who died from the disease, formed blood clots throughout their bodies.
However, the trials found blood thinners did not improve outcomes for critically ill patients who required ICU support. ....

Ryan Zarychanski , Ewan Goligher , University Of Toronto , University Of Manitoba , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , பல்கலைக்கழகம் ஆஃப் ம்யாநிடோப ,

Trials of blood thinners in critically ill COVID-19 patients pause due to futility


Credit: n/a
December 22 - Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients. Among critically ill COVID-19 patients requiring intensive care unit (ICU) support, full dose anticoagulation drugs did not improve outcomes. Enrollment continues for moderately ill hospitalized COVID-19 patients in the trials.
As is normal for clinical trials, these trials are overseen by independent boards that routinely review the data and are composed of experts in ethics, biostatistics, clinical trials, and blood clotting disorders. Informed by the deliberations of these oversight boards, all of the trial sites have paused enrollment of the most critically ill hospitalized patients with COVID-19. A potential for harm in this sub-group could not be excluded. Increased bleeding is a known complication of full-dose anticoagulation. The trials are working urge ....

Province Of Ontario , United Kingdom , Ryan Zarychanski , Ewan Goligher , Hospital Research Institute , University Health Network , National Health , National Institutes Of Health Research United Kingdom , National Institutes Of Health , Thistledown Foundation , Adaptive Platform Trial For Community , Lifearc Foundation , Canadian Institutes Of Health Research , University Of Manitoba , University Of Toronto , Research Manitoba , Research Council , Peter Munk Cardiac Centre , Cancercare Manitoba , Multi Factorial Adaptive Platform Trial , Community Acquired Pneumonia , Therapeutic Anticoagulation , Antithrombotics Inpatient , Antithrombotic Therapy , Ameliorate Complications , Toronto General Hospital Research Institute ,

Manitoba team embeds research in COVID-19 care


Manitoba team embeds research in COVID-19 care
Last Modified: 8:38 AM CST Monday, Dec. 14, 2020
| Updates
photos by MIKE DEAL / WINNIPEG FREE PRESS
Research co-ordinators Nora Choi, outside Grace Hospital, and Quinn Tays, outside St. Boniface General Hospital (below), are working with a team of researchers from other Winnipeg hospitals co-ordinating clinical trials with COVID-19 patients.
As COVID-19 hospitalization rates in the province continue to push intensive care units beyond their limits, a small team of local researchers is chasing the virus most of the world has been told to avoid at any cost.
As COVID-19 hospitalization rates in the province continue to push intensive care units beyond their limits, a small team of local researchers is chasing the virus most of the world has been told to avoid at any cost. ....

United States , Malak Abas , Ryan Zarychanski , Donald Trump , Nora Choi , Drug Administration , Antithrombotic Therapy , Ameliorate Complications , Multifactorial Adaptive Platform , Quinn Tays , ஒன்றுபட்டது மாநிலங்களில் , மாலக் அபா , டொனால்ட் துருப்பு , நோரா சோய் ,