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TB: How prior exposure to bacteria changes the lung's innate immune response and what it might mean for vaccines

TB: How prior exposure to bacteria changes the lung's innate immune response and what it might mean for vaccines
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Kevin-urdahl , Alissa-rothchild , Greg-olson , Seattle-children-research-institute , University-of-massachusetts-amherst , Animal-sciences-department , Massachusetts-amherst , Seattle-children , Research-institute , Trojan-horse , Dat-mai

Remodeling the immune system to fight tubercu

<p>Tuberculosis, caused by the bacterium <em>Mycobacterium tuberculosis</em> (Mtb) kills upwards of 1.6 million people a year, making it one of the leading causes of death by an infectious agent worldwide—and that number is only growing larger. How, exactly, Mtb evades the immune system isn’t yet known, but a collaborative team of researchers from the University of Massachusetts Amherst and Seattle Children’s Research Institute recently discovered something surprising: prior exposure to a genus of bacteria called <em>Mycobacterium</em> seems to remodel the first-line defenders in the body’s immune system. Furthermore, how those cells are remodeled depends on exactly how the body is exposed. These results, published recently in <a href="https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011871"><em>PLOS Pathogens</em></a><em>,</em> suggest that a more integrated treatment approach that targets all aspects of the  immune response could be a more effective strategy in the fight against tuberculosis.</p>

Daegan-miller , Kevin-urdahl , Alissa-rothchild , Seattle-children-research-instituteand , Animal-sciences-department , National-institute-of-allergy , National-institutes-of-health , Seattle-children-research-institute , University-of-massachusetts-amherst , Massachusetts-amherst , Seattle-children

Exposing How Tuberculosis Evades the Immune System

Exposing How Tuberculosis Evades the Immune System
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Alissa-rothchild , Kevin-urdahl , University-of-massachusetts-umass , Seattle-children-research-institute , Seattle-children , Research-institute , Trojan-horse ,

America's Game: America's Shame - Milwaukee Courier Weekly Newspaper

Assembly Bill 734, a proposed bill in California, could be the most powerful change to the game of football we’ve seen in years.

Wisconsin , United-states , California , Oregon , Seattle , Washington , North-carolina , America , Lenac-taylor , Seattle-children-research-institute , Wisconsin-interscholastic-athletic-association

Be Biopharma Expands Leadership Team as Company Transitions to Clinical Stage Organization

Be Biopharma Expands Leadership Team as Company Transitions to Clinical Stage Organization
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Be Biopharma to Present at the 42nd Annual J.P. Morgan Healthcare Conference

Be Biopharma to Present at the 42nd Annual J.P. Morgan Healthcare Conference
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Tech Moves: Google leaders join Seattle startup MotherDuck; Humanly adds a VP; and more

Tech Moves: Google leaders join Seattle startup MotherDuck; Humanly adds a VP; and more
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New Study Sheds Light On How The Brain Learns To Seek Reward

New Study Sheds Light On How The Brain Learns To Seek Reward
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Study sheds light on how the brain learns to seek reward

Dopamine's role in shaping behaviour and learning unveiled

Jonathan-tang , Allen-institute , Columbia-university , Champalimaud-centre-for-the , Seattle-children-research-institute , Champalimaud-centre , Seattle-children , Research-institute , Brain-learning , Eward , Opamine , Redit-assignment-problem

New study sheds light on how the brain learns to seek reward

/PRNewswire/ -- Imagine you're teaching a dog to play fetch. You throw a ball, and your dog sprints after it, picks it up, and runs back. You then reward your...

Rui-costa , Jonathan-tang , Paulg-allen , Columbia-university , Paulg-allen-frontiers-group , Allen-institute-for-cell-science , Columbia-university-zuckerman-mind-brain-behavior-institute , University-of-washington-medicine , Allen-institute-for-brain-science , Allen-institute , Champalimaud-centre-for-the , Seattle-children-research-institute