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Get latest articles and stories on Science at LatestLY. A new advance overcomes present limitations in spatial transcriptomics with a DNA nanotechnology-driven method called Light-Seq. Light-Seq allows researchers to geotag the full repertoire of RNA sequences with unique DNA barcodes exclusive to a few cells of interest. These target cells are selected using light under a microscope via a fast and effective photocrosslinking process, and their RNAs made available to next-generation sequencing with the help of a new DNA nanotechnology-driven technique. This entire process can then be repeated for different cell populations in the same sample. Science News | Scientists Turn Up Spotlight on Cells in Tissues So RNA Could Explain Disease and Biology. ....
A new advance overcomes present limitations in spatial transcriptomics with a DNA nanotechnology-driven method called Light-Seq. Light-Seq allows researchers to geotag the full repertoire of RNA sequences with unique DNA barcodes exclusive to a few cells of interest ....
Under the microscope, researchers often observe different cell types organizing themselves in peculiar patterns within tissues, or sometimes a rare cell type that stands out by occupying a unique position, exhibiting an unusual shape, or expressing a specific biomarker molecule. ....