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Science News | Scientists Turn Up Spotlight on Cells in Tissues So RNA Could Explain Disease and Biology

Get latest articles and stories on Science at LatestLY. A new advance overcomes present limitations in spatial transcriptomics with a DNA nanotechnology-driven method called Light-Seq. Light-Seq allows researchers to geotag the full repertoire of RNA sequences with unique DNA barcodes exclusive to a few cells of interest. These target cells are selected using light under a microscope via a fast and effective photocrosslinking process, and their RNAs made available to next-generation sequencing with the help of a new DNA nanotechnology-driven technique. This entire process can then be repeated for different cell populations in the same sample. Science News | Scientists Turn Up Spotlight on Cells in Tissues So RNA Could Explain Disease and Biology. ....

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Scientists turn up spotlight on cells in tissues so RNA could explain disease and biology

A new advance overcomes present limitations in spatial transcriptomics with a DNA nanotechnology-driven method called Light-Seq. Light-Seq allows researchers to geotag the full repertoire of RNA sequences with unique DNA barcodes exclusive to a few cells of interest ....

Germany , Boston , Massachusetts , United-states , Heidelberg , Baden-wüberg , Constance-cepko , Ninning-liu , Donald-ingber , Sinem-saka , Jocelyn-josie-kishi , Wyss-institute

Light-Seq technology for barcoding and deep-sequencing selected cell populations in tissues

Under the microscope, researchers often observe different cell types organizing themselves in peculiar patterns within tissues, or sometimes a rare cell type that stands out by occupying a unique position, exhibiting an unusual shape, or expressing a specific biomarker molecule. ....

Germany , Boston , Massachusetts , United-states , Heidelberg , Baden-wüberg , Constance-cepko , Ninning-liu , Donald-ingber , Sinem-saka , Jocelyn-josie-kishi , Emily-henderson

Turning spotlight on cells in tissues so RNA can tell their story

Turning spotlight on cells in tissues so RNA can tell their story
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