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Study elucidates the mode of action of SGLT2 inhibitors in diabetes


Study elucidates the mode of action of SGLT2 inhibitors in diabetes
Although SGLT-2 inhibitors are central to the treatment of diabetes, their exact mode of action was hitherto unknown. In a study conducted by a research group led by Peter Wolf, Martin Krssak and Michael Krebs from MedUni Vienna s Department of Medicine III, magnetic resonance spectroscopy (MRS) was used to show that there is a direct correlation between the elimination of glucose via the kidneys and new glucose production in the liver.
A single dose of the SGLT-2 inhibitor dapagliflozin gives rise to a beneficial regulation mechanism, in which glucose loss due to drug-induced SGLT-2 inhibition is exactly balanced out by an equal increase in new glucose production in the liver. The study has been published in the leading journal ....

Peter Wolf , Michael Krebs , Martin Krssak , Emily Henderson , Meduni Vienna Department Of Medicine , Division Of Endocrinology , Meduni Vienna Department Of Biomedical Imaging , Department Of Medicine , Meduni Vienna , Biomedical Imaging , பீட்டர் ஓநாய் , மைக்கேல் கிரெப்ஸ் , எமிலி ஹென்டர்சன் , பிரிவு ஆஃப் உட்சுரப்பியல் , துறை ஆஃப் மருந்து , உயிர் மருத்துவ இமேஜிங் , நீரிழிவு நோய் , வளர்சிதை மாற்றம் ,