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Newly Engineered Bacterium can Produce Carminic Acid


Newly Engineered Bacterium can Produce Carminic Acid
Written by AZoMApr 7 2021
A team of researchers from the Korea Advanced Institute of Science and Technology (KAIST) has designed a bacterium that can produce carminic acid a natural red colorant that is extensively used in cosmetics and food.
A schematic biosynthetic pathway for the production of carminic acid from glucose. Biochemical reaction analysis and computer simulation-assisted enzyme engineering were employed to identify and improve the enzymes (DnrFP217K and GtCGTV93Q/Y193F) responsible for the latter two reactions. Image Credit: The Korea Advanced Institute of Science and Technology (KAIST).
The researchers have demonstrated the entire biosynthesis of carminic acid from glucose in a newly designed ....

United States , South Korea , Dae Jang , Dongsoo Yang , National Research Foundation , Journal Of The American Chemical Society , Generation Collaborative Lab , Department Of Chemical , Novo Nordisk Foundation , Korea Advanced Institute Of Science , Ministry Of Science , Korea Advanced Institute , Canary Islands , Woo Dae Jang , Distinguished Professor Sang Yup Lee , American Chemical Society , Postdoctoral Researcher , Hyup Lee , Distinguished Professor , Technology Development Program , Solve Climate Changes , Systems Metabolic Engineering , ஒன்றுபட்டது மாநிலங்களில் , தெற்கு கொரியா , டே ஜங் , தேசிய ஆராய்ச்சி அடித்தளம் ,

Microbial production of a natural red colorant carminic acid


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IMAGE: Figure: A schematic biosynthetic pathway for the production of carminic acid from glucose. Biochemical reaction analysis and computer simulation-assisted enzyme engineering was employed to identify and improve the enzymes (DnrFP217K.
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Credit: KAIST
A research group at KAIST has engineered a bacterium capable of producing a natural red colorant, carminic acid, which is widely used for food and cosmetics. The research team reported the complete biosynthesis of carminic acid from glucose in engineered Escherichia coli. The strategies will be useful for the design and construction of biosynthetic pathways involving unknown enzymes and consequently the production of diverse industrially important natural products for the food, pharmaceutical, and cosmetic industries. ....

United States , Dae Jang , Dongsoo Yang , National Research Foundation , Journal Of The American Chemical Society , Generation Collaborative Lab , Department Of Chemical , Novo Nordisk Foundation , Ministry Of Science , Canary Islands , Woo Dae Jang , Distinguished Professor Sang Yup Lee , American Chemical Society , Distinguished Professor Sang Yup , Technology Development Program , Solve Climate Changes , Systems Metabolic Engineering , Sangyup Lee , ஒன்றுபட்டது மாநிலங்களில் , டே ஜங் , தேசிய ஆராய்ச்சி அடித்தளம் , இதழ் ஆஃப் தி அமெரிக்கன் இரசாயன சமூகம் , ஜெநரேஶந் கூட்டு ஆய்வகம் , துறை ஆஃப் இரசாயன , அமைச்சகம் ஆஃப் அறிவியல் , கேனரி தீவுகள் ,

Expanding the biosynthetic pathway via retrobiosynthesis

KAIST metabolic engineers presented the bio-based production of multiple short-chain primary amines that have a wide range of applications in chemical industries for the first time. The research team designed the novel biosynthetic pathways for short-chain primary amines by combining retrobiosynthesis and a precursor selection step. ....

Nature Communications , National Research Foundation , Department Of Chemical , Ministry Of Science , Distinguished Professor Sang Yup Lee , Biomolecular Engineering , Technology Development Program , Solve Climate Changes , Systems Metabolic Engineering , Biomedical Environmental Chemical Engineering , இயற்கை தகவல்தொடர்புகள் , தேசிய ஆராய்ச்சி அடித்தளம் , துறை ஆஃப் இரசாயன , அமைச்சகம் ஆஃப் அறிவியல் , புகழ்பெற்ற ப்ரொஃபெஸர் பாடினார் ஆம் லீ , உயிர் மூலக்கூறு பொறியியல் , தொழில்நுட்பம் வளர்ச்சி ப்ரோக்ர்யாம் , தீர்க்க காலநிலை மாற்றங்கள் , அமைப்புகள் வளர்சிதை மாற்ற பொறியியல் , உயிரி தொழில்நுட்பவியல் , உயிர் மருத்துவ சுற்றுச்சூழல் இரசாயன பொறியியல் ,