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Understanding how chikungunya virus affects the brain and body

The chikungunya virus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes and responsible for more than 900 deaths in Brazil since it arrived around ten years ago, is capable of spreading through the blood, reaching multiple organs and crossing the blood-brain barrier, which protects the central nervous system. ....

City Of , United Kingdom , United States , Luiz Proen , Melinda Gates Foundation , University Of Campinas Unicamp , Imperial College London , Technological Development Cnpq , Central Public Health Laboratory Of Cear , University Of Kentucky , Institute Of Biology , University Of Kentucky United States , National Institutes Of Health , Brazilian Ministry Of Science , Paulo Research Foundation , Global Virus Network , Drug Administration , Texas Medical Branch , Burroughs Wellcome Fund , Brazilian National Council For Scientific , Cell Host , State University , Central Public Health Laboratory , Marciel De Souza , Brazilian National Council , Technological Development ,

Chikungunya Virus Causes Death by Attacking Organs, Dysregulating Immunity: Study

Chikungunya Virus Causes Death by Attacking Organs, Dysregulating Immunity: Study
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United States , City Of , United Kingdom , Luiz Proen , University Of Kentucky United States , Texas Medical Branch , Brazilian National Council For Scientific , Burroughs Wellcome Fund , Central Public Health Laboratory Of Cear , Global Virus Network , Paulo Research Foundation , University Of Campinas Unicamp , Brazilian Ministry Of Science , Drug Administration , National Institutes Of Health , Technological Development Cnpq , Imperial College London , Institute Of Biology , University Of Kentucky , Melinda Gates Foundation , Cell Host , State University , Central Public Health Laboratory , William Marciel De Souza , Brazilian National Council , Technological Development ,

Academia needs radical change — mothers are ready to pave the way

The research system must lose its overly rigid attitude towards career progression — and mothers are uniting to make that happen. The research system must lose its overly rigid attitude towards career progression — and mothers are uniting to make that happen. ....

United States , Rio De Janeiro , Estado Do Rio , Rio Grande Do Sul , Porto Alegre , Maria Carlotto , Institute Of Biosciences , University Of Rio Grande Do Sul , Centre For Biotechnology , National Council For Scientific , Technological Development Cnpq , Parent In Science Movement , Serrapilheira Institute , National Council , Technological Development , Federal University , Rio Grande , Science Movement , Latin America ,

Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: A cost-effectiveness analysis using a transmission model

Author summary Why was this study done? Radical cure with primaquine or recently approved tafenoquine is required to clear the dormant liver parasites of vivax malaria. While single-dose tafenoquine overcomes the barrier of patient adherence to the current 7-day primaquine treatment, it costs more and requires screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency. While the impact of changing policies to tafenoquine after G6PD screening on transmission has been evaluated, the associated costs and cost-effectiveness will be important considerations for policymakers. What did the researchers find? Using an economic evaluation model coupled with a transmission model, we found that prescribing tafenoquine to vivax malaria patients without G6PD deficiency would be highly likely to be cost-effective in Brazil. Tafenoquine will be particularly cost-effective in settings where patient adherence to the current 7-day treatment is low and when paediatric tafenoquine is available ....

Papua New Guinea , United States , South Korea , Republic Of Korea , Monte Carlo , Jamesg Beeson , Brazilian Unified Health System , National Malaria Control Programme , Ministry Of Health Brazil , Burnet Institute , Technological Development Cnpq , World Health Organisation , Melinda Gates Foundation , National Council For Scientific , National Commission For The Incorporation Of Technologies , Ministry Of Health , National Malaria Prevention , Creative Commons Attribution License , National Council , Technological Development , United States Dollars , South America , While Scenarios , Epidemiological Surveillance Information System , National Commission , Brazilian Unified Health ,

Why 2023 was a bittersweet year for Brazilian science

Expectations were high after Luiz Inácio Lula da Silva won the presidency. But some scientists are frustrated at the slow pace of change. Expectations were high after Luiz Inácio Lula da Silva won the presidency. But some scientists are frustrated at the slow pace of change. ....

United States , Minas Gerais , Sao Paulo , Michigan State University , Rio De Janeiro , Estado Do Rio , Santa Catarina , East Lansing , Oswaldo Cruz , Rio Grande Do Sul , Belo Horizonte , Michel Temer , Carlos Nobre , Luciana Santos , Leonel Perondi , Luiz Inacio Lula , Ricardo Galv , Adele Benzaken , Marcus Vin , Denise Carvalho , Nelson Almeida , Luis Fernandes , Renato Janine Ribeiro , Brazil Ministry Of Economy , Technological Development Cnpq , University Of Minas Gerais ,