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Comprehensive clinical sequencing opens door to the promise of precision medicine

Comprehensive clinical sequencing opens door to the promise of precision medicine
prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.

Manjusha Pande , Annastasia Ouma , Michael Rusch , Chimene Kesserwan , Antonina Silkov , Emily Quinn , Zhaohui Gu , Roya Mostafavi , Michael Edmonson , Jian Wang , Michael Clay , Andrew Thrasher , Jeffery Klco , Brent Orr , Alberto Pappo , Lu Wang , Jinghui Zhang , Delaram Rahbarinia , Samuel Brady , Elise Gerhardt , Cheng Chang , Armita Bahrami , Raman Patel , David Wheeler , Rose Mcgee , Jamesr Downing ,

Analysis reveals origins of a leukemia that straddles diagnostic categories

Analysis reveals origins of a leukemia that straddles diagnostic categories
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Cyrus Mehr , Kirsten Dickerson , Zhaohui Gu , Jing Ma , Ilaria Iacobucci , William Evans , Mary Relling , Ryan Hiltenbrand , Wenjian Yang , Tamara Westover , Xiaolong Chen , Xiaotu Ma , Jeffery Klco , Kathryn Roberts , Junj Yang , Charles Mullighan , Jinghui Zhang , Lindsey Montefiori , Cheng Chang , Beisi Xu , Henry Schueler , Sherif Abdelhamed , Shunsuke Kimura , Claudia Haferlach , Zhongshan Cheng , Sonja Bendig ,

Risk-directed childhood leukemia treatment takes a step forward


Date Time
Risk-directed childhood leukemia treatment takes a step forward
Corresponding author Ching-Hon Pui, M.D., St. Jude Oncology Department chair, helped discover how genomic analysis can improve outcomes for children with acute lymphoblastic leukemia.
Comprehensive genomic analyses have helped researchers identify more than 20 subtypes of acute lymphoblastic leukemia (ALL) based on the genetic mutations that drive the disease. Research led by St. Jude Children’s Research Hospital scientists showed that combining these data with leukemia response measurements improves prediction of relapse risk.
Currently, patients’ response to treatment influences the type of therapy administered for ALL. This risk-directed approach involves assessing minimal residual disease, the level of leukemic cells in the blood or bone marrow of patients at defined points during treatment ....

Deqing Pei , Elaine Coustan Smith , Zhaohui Gu , Dario Campana , William Evans , Mary Relling , John Choi , Jeffrey Rubnitz , Sima Jeha , Tanja Gruber , Susana Raimondi , Charles Mullighan , Junj Yang , Kathryn Roberts , Seth Karol , Samuel Brady , Jamesr Downing , Raul Ribeiro , Hiroto Inaba , Jude Oncology Department , Judeoncology Department , Jude Children Research Hospital , National University Of Singapore , National Institutes Of Health , Jude Department Of Pathology , Ching Hon Pui ,