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Last modified on Fri 4 Jun 2021 06.58 EDT In the 1950s the US chemist Helen Murray Free, who has died aged 98, was responsible for developing glucose dipsticks. Their use led to much simpler medical screening methods that are still widely used today for pregnancy tests, the diagnosis and monitoring of diabetes, and to detect and monitor a range of kidney, liver and metabolic disorders and other medical conditions. Before then, without central testing laboratories, if a patient needed to be tested for diabetes the analysis work was done in the doctor’s office: mixing urine with chemicals such as copper sulphate, heating it over a Bunsen burner and looking for a red-orange precipitate indicating sugar. It was time-consuming, restricting the number of tests a doctor carried out, and inconclusive, as it did not differentiate between glucose (indicating diabetes) and other sugars. ....
Helen Murray Free with her husband and scientific collaborator Alfred in 1955 Credit: BAYER Helen Murray Free, who has died aged 98, was the co-developer, with her husband Alfred Free, of Clinistix, the first dip-and-read diagnostic test for diabetes and for monitoring glucose levels in urine, an achievement that revolutionised diagnostic testing. Before the introduction of Clinistix in 1956, laboratory technicians tested for diabetes by adding a reagent to urine in a test tube and then heating the mixture over a Bunsen burner, a process that was not only cumbersome but also imprecise because it could not distinguish glucose from other sugars. Working at Miles Laboratories in Indiana, the Frees worked out how to impregnate thin strips of filter paper with chemicals that changed colour based on the concentration of glucose present in the urine, the intensity of the resulting blue-green depending on the amount of peroxide, and hence, glucose, in the sample. ....
Die Stadt Falkenstein und ihr Verhältnis zu Alfred Roßner | Freie Presse freiepresse.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from freiepresse.de Daily Mail and Mail on Sunday newspapers.