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COVID-19: Tiefrgeifende Umprogrammierung des angeborenen Immunsystems

COVID-19: Tiefrgeifende Umprogrammierung des angeborenen Immunsystems
heilpraxisnet.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from heilpraxisnet.de Daily Mail and Mail on Sunday newspapers.

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A CRISPR on-off switch for genes controls expression without altering DNA

April 12, 2021 A new gene silencing tool allows scientists to switch genes on and off without altering genetic sequences. The tool, described in a paper published in
Cell on April 9, uses a modified CRISPR-Cas9 system to introduce reversible epigenetic changes that control gene expression.
The classic CRISPR-Cas9 system led to an explosion in gene editing studies since it was first developed almost a decade ago. It became quickly popular thanks to its ease of use compared to previous gene editing methods.
CRISPR-Cas9 uses guide RNA to chaperone the Cas9 nuclease to a particular site in the DNA and create a double-strand break. By adding a specially designed short sequence of DNA, scientists can introduce permanent genetic changes to the cell. This oligonucleotide is used as a template by the cell when repairing the double-strand break, incorporating the sequence into the cell s genome. However, this approach can cause unintended genetic changes. ....

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Autism may be Detected by Sperm Epigenetics

Autism may be Detected by Sperm Epigenetics
by Karishma Abhishek on
January 14, 2021 at 12:14 PM
Biomarkers in human sperm can indicate if a father can inherit autism spectrum disorder to his children. The biomarkers are found to be epigenetic - molecular changes in factors regulating genome activity, such as gene expression independent of DNA sequence. It can be passed down to future generations, as per a study published in the journal
Clinical Epigenetics.
This particular set of genomic features were known as
DNA methylation regions - a chemical modification that happens when a methyl group attaches to a DNA strand and can turn genes on or off. Sperm epigenetics, specifically DNA methylation was studied from the sperm samples of two groups of men: 13 who had fathered sons with autism, and 13 who had children without the disorder. ....

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VolitionRx Limited Awarded an Additional $4 Million in Non-Dilutive Funding

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AUSTIN, Texas, Jan. 6, 2021 /PRNewswire/ VolitionRx Limited (NYSE AMERICAN: VNRX) ( Volition ) today announced it has been awarded additional non-dilutive funding totaling approximately $4 million from the Walloon Region and Namur Invest, Belgium. To date, Agencies from the Walloon Region have awarded Volition an aggregate of approximately $13 million in non-dilutive funding including this most recent award. This additional funding consisted of a cash grant of $1.3 million and $2.7 million in loans.
It is a key part of our financing strategy to actively seek non-dilutive funding as this provides additional cash at favorable terms to support the Company s continued development, and this latest funding takes the total non-dilutive funding to-date from all sources to over $15 million, commented Cameron Reynolds, President and Chief Executive Officer of Volition. Mr. Reynolds added, We are delighted with the great progress we are ....

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