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SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees


Abstract
The emergence of SARS-CoV-2 variants harboring mutations in the spike (S) protein has raised concern about potential immune escape. Here, we studied humoral and cellular immune responses to wild type SARS-CoV-2 and the B.1.1.7 and B.1.351 variants of concern in a cohort of 121 BNT162b2 mRNA-vaccinated health care workers (HCW). Twenty-three HCW recovered from mild COVID-19 disease and exhibited a recall response with high levels of SARS-CoV-2-specific functional antibodies and virus-specific T cells after a single vaccination. Specific immune responses were also detected in seronegative HCW after one vaccination, but a second dose was required to reach high levels of functional antibodies and cellular immune responses in all individuals. Vaccination-induced antibodies cross-neutralized the variants B.1.1.7 and B.1.351, but the neutralizing capacity and Fc-mediated functionality against B.1.351 was consistently 2- to 4-fold lower than to the homologous virus. In additi ....

United Kingdom , Fox Chase Cancer Center , United States , South Africa , Kerrys Campbell , Biosystems Taqpath , Europe Gmb , Wantai Biological Pharmacy Enterprise Co Ltd , Gibco Roswell Park Memorial Institute , S Specific Igg , S Specifict Cell , Applied Biosystems Taqpath , Thermofisher Scientific , Target Failure , Stemcell Technologies , Optical Density , Binding Antibody Units , Sino Biological , Perry Laboratories , Immunospot Image Analyzer , Southern Biotech , Aqua Dead Cell , Creative Commons Attribution , ஒன்றுபட்டது கிஂக்டம் , நரி துரத்து புற்றுநோய் மையம் , ஒன்றுபட்டது மாநிலங்களில் ,