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New tools enable rapid analysis of coronavirus sequences and tracking of variants


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IMAGE: In this example of UShER results, displayed using Nextstrain, sequences representing a hypothetical outbreak are yellow, previously sampled sequences are blue, and branches are labeled by nucleotide mutations.
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Credit: UC Santa Cruz Genomics Institute
The COVID-19 pandemic has spurred genomic surveillance of viruses on an unprecedented scale, as scientists around the world use genome sequencing to track the spread of new variants of the SARS-CoV-2 virus. The rapid accumulation of viral genome sequences presents new opportunities for tracing global and local transmission dynamics, but analyzing so much genomic data is challenging.
There are now more than a million genome sequences for SARS-CoV-2. No one had anticipated that number when we started sequencing this virus, said Russ Corbett-Detig, assistant professor of biomolecular engineering at UC Santa Cruz. ....

United States , Australian Capital Territory , Angie Hinrichs , Yatish Turakhia , Russ Corbett Detig , David Haussler , Landen Gozashti , Bryan Thornlow , European Bioinformatics Institute , Alfredp Sloan Foundation , Genomics Institute , National Institutes Of Health , Uc Santa Cruz Genomics Institute , Robert Lanfear At Australian National University , Cruz Genomics Institute , Ultrafast Sample Placement , Existing Trees , Epidemiology Toolkit , Nicola De Maio , Robert Lanfear , Australian National University , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , ஆஸ்திரேலிய மூலதனம் பிரதேசம் , ஆங்கி ஹின்ரிச் , யத்திஷ் துராகியா ,

NSU researcher part of a flagship study on vertebrate genomes


Credit: Genome 10K Project
Study Take-Aways
Unprecedented novel discoveries have implications for characterizing biodiversity for all life, conservation, and human health and disease.
o This finding provides novel avenues of research to increase immune defenses, particularly relevant for emerging infectious diseases, such as the current COVID-19 pandemic.
The flagship paper presented whole genome sequence analyses of 16 vertebrate species to illustrate high quality, near error free, near complete, low cost reference genome assemblies.
o Though near 400 species have been sequenced at some level, the quality today reflects a quantum leap in precision sequence details and discovery.
FORT LAUDERDALE/DAVIE, Fla. - Two decades ago, the full genome sequence of humankind was released. It was funded by international government and philanthropic sources at a cost of billions of dollars. ....

United States , Fort Myers , New York , United Kingdom , Chevy Chase , San Diego , Puerto Rico , Fort Lauderdale , National Institutes Of Health , New Zealand , Department Of Education , District Of Columbia , Rockefeller University , San Diego Zoo , Sankt Peterburg , Palm Beach , Oxford Nanopore , Stephen Obrien , Richard Durbin , Pacific Biosciences , Erich Jarvis , Adam Phillippy , Kerstin Howe , Halmos College Of Arts , University Of Cambridge , Art Museum Fort Lauderdale ,