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Keep them breathing: Cystic fibrosis pathophysiology, diagno... : Journal of the American Academy of PAs


PRESENTATION
The classic presentation of CF is respiratory insufficiency or gastrointestinal (GI) disturbances in an infant. Signs of CFTR dysfunction within the GI track normally present earlier than respiratory insufficiencies. Specifically, meconium ileus will by symptomatic before results of neonatal screening are available.
6 Due to the recent requirement of newborn screening throughout the United States, CF often is diagnosed before symptoms are noted. The most common symptoms in children are a chronic cough and wheezing associated with malabsorption in the GI tract and failure to thrive.
1 Infants may have a meconium ileus, which can help lead to the diagnosis.
Other significant signs and symptoms are nasal polyps, bronchiectasis, pancreatic insufficiency, and sterility. ....

United States , Pediatric Endocrine Society , American Diabetes Association , Cystic Fibrosis Foundation , ஒன்றுபட்டது மாநிலங்களில் , குழந்தை நாளமில்லா சமூகம் , அமெரிக்கன் நீரிழிவு நோய் சங்கம் , சிஸ்டிக் ஃபைப்ரோஸிஸ் அடித்தளம் ,