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SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies


SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies
A short report recently published in the
Journal of Infectious Diseases demonstrates how spike mutations L452R and E484Q found in the variant B.1.617.1 of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) each confer modestly diminished sensitivity to Pfizer-BioNTech (BNT162b2) mRNA vaccine-elicited antibodies – with combined mutations having a similar impact as either one of them alone.
Full global control of the coronavirus disease (COVID-19) pandemic has yet to be achieved, despite the fact that highly effective vaccines against its causative agent, SARS-CoV-2, are now at our disposal. This is partly due to the emergence of new viral variants with antibody escape mutations. ....

United Kingdom , Ravi Gupta , Cambridge Institute Of Therapeutic Immunology Infectious Disease , University Of Cambridge United Kingdom , Department Of Medicine , Infectious Diseases , Cambridge Institute , Therapeutic Immunology , Infectious Disease , ஒன்றுபட்டது கிஂக்டம் , ரவி குப்தா , கேம்பிரிட்ஜ் நிறுவனம் ஆஃப் சிகிச்சை நோயெதிர்ப்பு தொற்று நோய் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் ஒன்றுபட்டது கிஂக்டம் , துறை ஆஃப் மருந்து , தொற்று நோய்கள் , கேம்பிரிட்ஜ் நிறுவனம் , சிகிச்சை நோயெதிர்ப்பு , தொற்று நோய் ,

Digital Self-Monitoring Effective for Weight Loss, Healthy Lifestyle


Credit: Getty Images.
HealthDay News Digital self-monitoring of physical activity and diet is an effective intervention to support weight loss in adults with obesity or overweight, according to a review published online in
Obesity Reviews.
Rhiannon Berry, from the Cambridge Institute of Public Health in the United Kingdom, and colleagues conducted a systematic literature review to assess whether digital self-monitoring of diet and physical activity is effective at supporting weight loss, increasing physical activity, and improving eating behavior in adults with obesity or overweight.
Based on 12 identified randomized controlled trials, the researchers found that digital self-monitoring of both diet and physical activity had a statistically significant effect for supporting weight loss (mean difference, −2.87), improving moderate physical activity (standardized mean difference, 0.44), and reducing calorie intake (mean difference, −181.71). Furthermore, ....

United Kingdom , Rhiannon Berry , Cambridge Institute Of Public Health , Healthday News , Cambridge Institute , Public Health , ஒன்றுபட்டது கிஂக்டம் , ரீயேநந் பெர்ரி , கேம்பிரிட்ஜ் நிறுவனம் ஆஃப் பொது ஆரோக்கியம் , கேம்பிரிட்ஜ் நிறுவனம் , பொது ஆரோக்கியம் ,