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Clopidogrel superior to aspirin for long-term post-stent maintenance


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Clopidogrel outperformed aspirin in what is believed to be the first and largest randomized trial to compare the effectiveness of the two antiplatelet drugs as long-term maintenance therapy for patients who had no adverse events after one year of dual antiplatelet therapy (DAPT) following the insertion of a coronary stent. After two years of follow-up, chronic maintenance therapy with clopidogrel resulted in a 30% reduction in deaths, heart attacks, strokes or major bleeding events, according to research presented at the American College of Cardiology s 70th Annual Scientific Session.
These data confirm our working hypothesis that long-term maintenance antiplatelet monotherapy with clopidogrel produces better outcomes than aspirin in patients who are adverse event-free at one year after coronary stenting, said Hyo-Soo Kim, MD, PhD, professor of internal medicine at Seoul National University Hospital in South Korea and lead author of the study. ....

Soult Ukpyolsi , South Korea , Hyo Soo Kim , Nicole Napoli , Yann Nguyen , Antiplatelet Monotherapy , Seoul National University Hospital , American College Of Cardiology , Korean Ministry Of Health , American College , Annual Scientific , South Korean Ministry , Host Exam Randomized Controlled Trial , தெற்கு கொரியா , ஹயோ சூ கிம் , நிக்கோல் ந்யாபலீ , ஆண்டு ஂக்யந் , சியோல் தேசிய பல்கலைக்கழகம் மருத்துவமனை , அமெரிக்கன் கல்லூரி ஆஃப் இருதயவியல் , கொரியன் அமைச்சகம் ஆஃப் ஆரோக்கியம் , அமெரிக்கன் கல்லூரி , ஆண்டு அறிவியல் , தெற்கு கொரியன் அமைச்சகம் ,

Scientists Identify Genetic Pathway that Suppresses Lou Gehrig's Disease


Date Time
Scientists Identify Genetic Pathway that Suppresses Lou Gehrig’s Disease
Professor Chunghun Lim and his research team in the Department of Biological Sciences unveiled a neuroprotective pathway that suppresses Lou Gehrig’s Disease (ALS).
Nucleocytoplasmic transport (NCT) defects have been implicated in neurodegenerative diseases, such as C9ORF72-associated amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). In this study, the research team has identified a neuroprotective pathway of like-Sm protein 12 (LSM12) and exchange protein directly activated by cyclic AMP 1 (EPAC1) that sustains the nucleocytoplasmic RAN gradient and thereby suppresses NCT dysfunction by the C9ORF72-derived poly (glycine-arginine) protein. ....

South Korea , Lou Gehrig , Jongbo Lee , Department Of Biological Sciences , National Research Foundation Of Korea , Korea Health Technology , Suh Kyungbae Foundation , Korean Ministry Of Health , Professor Chunghun Lim , Biological Sciences , National Research Foundation , Korea Health Technology Rd Project , Korean Ministry , Ju Min Park , Ji Hyung Kim , Ministry Of Health , Amyotrophic Lateral Sclerosis , Health Technology , Cell Nucleus , தெற்கு கொரியா , லூ கேஹ்ரிக் , துறை ஆஃப் உயிரியல் அறிவியல் , தேசிய ஆராய்ச்சி அடித்தளம் ஆஃப் கொரியா , கொரியா ஆரோக்கியம் தொழில்நுட்பம் , கொரியன் அமைச்சகம் ஆஃப் ஆரோக்கியம் , உயிரியல் அறிவியல் ,