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Local jab shows promise, more analysis underway

The results of the first phase of human trials of a homegrown Covid-19 vaccine candidate being developed by the Government Pharmaceutical Organisation (GPO) and Mahidol University's faculty of tropical medicine are promising, researchers say. ....

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Sorely Needed Dengue Vaccine Gets a Boost from Immune Profiling

Sorely Needed Dengue Vaccine Gets a Boost from Immune Profiling
Source: Pixabay
May 26, 2021
A new study in the journal
Nature Communications compares changes in gene expression in immune cells in humans before, during, and after infection with a partially weakened Dengue virus (rDEN2Δ30, ClinicalTrials.gov NCT02021968). Live, weakened or “attenuated” viruses are the basis for the most effective and durable vaccines against many viral diseases.
The study finds that while the expression of some inflammatory genes, such as genes for type I interferon and viral restriction pathways, increases when the virus is present in blood and returns to baseline upon virus clearance, the expression of other genes that code for immune regulatory factors, in immune cells such as antibody-producing cells, remain at elevated levels even when the virus is no longer in the patient’s bloodstream. ....

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Dengue immune function discovery could benefit much-needed vaccine development

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Despite a daunting more than 130 million cases of SARS-CoV-2 infections to date worldwide, another global pathogen - the Aedes mosquito-borne dengue virus - saw a record number of over 400 million cases in 2019. But vaccine development has been challenging due to the need to protect equally against all four dengue strains. The discovery of new possible biomarkers to predict clinical and immune responses to dengue virus infection, published today in
Nature Communication, could be critical to informing future vaccines.
As with SARS-CoV-2 infection, the effects of dengue virus infection can range from asymptomatic to severe disease that can be fatal. Climate change has expanded the viruses geographic distribution far beyond tropical areas like Southeast Asia and Latin America to the southern U.S. and Europe. Only one vaccine, Dengvaxia, has been approved for a subset of at-risk individuals in endemic areas. ....

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2021 – 2022 University Scholars

Beth Kirkpatrick, MD; Donna Rizzo and Kimberly Vannest named University Scholars for 2021 – 2022 academic year.
The University of Vermont Graduate College is pleased to announce the 2021-2022 University Scholars. The University Scholars program recognizes distinguished UVM faculty members for sustained excellence in research, scholarship and creative arts.
Basic and Applied Sciences
Professor and Chair, Department of Microbiology and Molecular Genetics
Dr. Kirkpatrick is Professor and Chair in the Department of Microbiology and Molecular Genetics at the University of Vermont (UVM) Larner College of Medicine. She holds a secondary appointment in the Department of Medicine, Division of Infectious Diseases and is an attending physician at the UVM Medical Center. She received her M.D. at Albany Medical College and performed an Internal Medicine residency and chief residency at the University of Rochester. She completed subspecialty and research training in Infe ....

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A COVID-19 Vaccine Volunteer Explains Why He Got a Shot in the Arm

Joshua Schupp-Star getting vaccinated
Joshua Schupp-Star can give you many reasons why he volunteered to join the clinical trial of an experimental COVID-19 vaccine at the University of Vermont s Vaccine Testing Center. All can be summarized in one word: hope.
After receiving my first dose, I got a taste of the freedom that existed before the pandemic, said Schupp-Star, who is among the 284 volunteers in Vermont to receive an as-yet-unapproved vaccine made by British-Swedish drug manufacturer AstraZeneca. It s such a liberating feeling to walk around in the community knowing that my body had some protection against the virus that has caused so much suffering in the world. ....

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