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Pirfenidone reduces scar tissue in patients with heart failure

Patients with heart failure with preserved ejection fraction who took the antifibrotic drug pirfenidone saw a significant reduction in a marker of heart muscle scarring compared with patients who received a placebo, based on findings from an early-phase trial presented at the American College of Cardiology s 70th Annual Scientific Session. ....

United Kingdom , Chris Miller , Nicole Napoli , Yann Nguyen , National Institute For Health Research Clinician Scientist , Manchester University , Roche Products , Roche Diagnostics International , National Institute For Health Research United Kingdom , American College Of Cardiology , University Of Manchester , American College , Annual Scientific , National Institute , Health Research Clinician Scientist , Health Research , Heart Failure With Preserved Ejection Fraction , Medicine Health , Clinical Trials , Death Dying , Pharmaceutical Science , ஒன்றுபட்டது கிஂக்டம் , கிறிஸ் மில்லர் , நிக்கோல் ந்யாபலீ , ஆண்டு ஂக்யந் , மான்செஸ்டர் பல்கலைக்கழகம் ,

B.1.1.7. variant more transmissible, does not increase severity, Lancet studies suggest

B.1.1.7. variant more transmissible, does not increase severity, Lancet studies suggest
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United Kingdom , City Of , United Kingdom General , Mark Graham , Britta Jewell , Barnaby Edward Young , Sean Wei Xiang , Eleni Nastouli , Claire Steves , King College London , National Institute For Health Research United Kingdom , Department Of Health United Kingdom , Academy Of Medical Sciences , Lancet Public Health , University College London Hospital , Middlesex University Hospital , University College London Hospitals , Imperial College London , National Centre For Infectious Diseases , Sciences Research Council United Kingdom , Sciences Research Council , Public Health England , Biomedical Research Centre , Alzheimer Society , Research Council United Kingdom , United Kingdom Genetics Consortium ,

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Abstract
While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral lung diseases remain poorly characterized. We analyzed plasma samples from 471 hospitalized patients recruited through the prospective multicenter ISARIC4C study and 39 outpatients with mild disease, enabling extensive characterization of responses across a full spectrum of COVID-19 severity. Progressive elevation of levels of numerous inflammatory cytokines and chemokines (including IL-6, CXCL10, and GM-CSF) were associated with severity and accompanied by elevated markers of endothelial injury and thrombosis. Principal component and network analyses demonstrated central roles for IL-6 and GM-CSF in COVID-19 pathogenesis. Comparing these profiles to archived samples from patients with fatal influenza, IL-6 was equally elevated in both conditions whereas GM-CSF was prominent on ....

United Kingdom , United States , City Of , La Jolla , Oxford Immunotech , Jeremyj Farrar , Quanterix Billerica , Nahoko Shindo , Milliporesigma Burlington , Ethics Review Committee , Imperial Biomedical Research Centre , Scotlanda Research Ethics Committee Ref , Oxfordc Research Ethics Committee , Material Access Committee , Zoonotic Infections At University Of Liverpool , Health Protection Research Unit , World Health Organization , Tissue Bank Ethics Committee Approval , Health Protection Research Senior Investigator , Liverpool Experimental Cancer Medicine Centre , Infections At Imperial College London , United Kingdom Coronavirus Immunology Consortium , National Institute For Health Research United Kingdom , Fulham Research Ethics Committee , Department For International Development , Melinda Gates Foundation ,

Helping behavior may mitigate academic risk for children from low-income neighborhoods

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Children raised in neighborhoods with low socio-economic status are at risk for low academic achievement. A new longitudinal study followed young children from such neighborhoods from birth until age seven to explore whether children s capacity to act kindly or generously towards others (prosocial behavior) - including peers, teachers, and family - is linked to their ability to perform well in school. The study showed that prosocial behavior may mitigate academic risk across early childhood.
The findings were published in a
Child Development article written by researchers at Stanford University and the University of Leeds, and the Bradford Institute for Health Research. ....

United States , United Kingdom , Emma Armstrong Carter , National Institute For Health Research United Kingdom , Child Development , Bw Stanford University , Stanford University Graduate School Of Education , Society For Research , L Jb University Of Leeds , Health Research , Institute Of Education Sciences United States , National Institutes Of Health United States , Research Mobility Award , Welcome Trust United Kingdom , He Stanford University , Jg Stanford University , Child Development Inc , Bradford Institute For Health Research , University Of Leeds , Research Council United Kingdom , European Research Council , Stanford University , Bradford Institute , Stanford University Graduate School , White European , South Asian ,

Trial shows blood thinners decrease need for life support in hospitalized COVID-19 patients - CHVNRadio: Southern Manitoba's hub for local and Christian news, and adult contemporary Christian programming.

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An international trial tested in over 300 hospitals around the world have concluded that blood thinners improve the outcome for hospitalized COVID-19 patients.
The University of Manitoba released the conclusion of the trials in a media release on Friday.
The introduction of full-dose blood thinners for patients who had mild symptoms of the virus showed a reduced need for organ support.
The release says that three clinical trial platforms spanning five continents in over 300 hospitals have been working together since May 2020 to urgently test whether there is a greater benefit of full doses of heparin (blood thinners) to treat adults hospitalized for non-critical COVID-19 illness compared to the lower dose typically administered to prevent blood clots in hospitalized patients. ....

New Zealand , United Kingdom , Ryan Zarychanski , Ewan Goligher , National Health , National Institute For Health Research United Kingdom , Lung Blood Institute , Canadian Institutes Of Health Research , Lifearc Foundation , University Of Manitoba , Translational Breast Cancer Research Consortium , While Doing Program , Research Council , National Heart , Health Research Council Of New Zealand , Cancercare Manitoba , Antithrombotic Therapy , Ameliorate Complications , Canadian Institutes , Health Research , Blood Institute , National Institute , Medical Research Council , Health Research Council , புதியது ஜீலாந்து , ஒன்றுபட்டது கிஂக்டம் ,