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Study finds consistent neuroinflammatory response after intracerebral hemorrhage


Study finds consistent neuroinflammatory response after intracerebral hemorrhage
Understanding how the immune system responds to acute brain hemorrhage could open doors to identifying treatments for this devastating disease. However, up until now, there has been limited information on inflammation in the brain from human patients, especially during the first days after a hemorrhagic stroke.
This led a team of researchers to partner with a large clinical trial of minimally-invasive surgery to tackle defining the human neuroinflammatory response in living patients.
Our goal was to find out, for the first time, how certain key cells of the immune system are activated when they enter the brain after a hemorrhage and how this may shift over the first week. This is a critical time for our patients. ....

United States , Dan Hanley , Lauren Sansing , Michael Askenase , Alex Shalek , Charles Matouk , Emily Henderson , Research Scientist , American Heart Association , Sansing Lab , Academic Chief , Vascular Neurology , Associate Professor , Science Immunology , Associate Research Scientist , Brittany Goods , Neurovascular Surgery , Brain Hemorrhage , Clinical Trial , Immune Response , Immune System , ஒன்றுபட்டது மாநிலங்களில் , டான் ஹான்லி , லாரன் சான்சிங் , அலெக்ஸ் ஷாலெக் , எமிலி ஹென்டர்சன் ,

Leeds native turned children's medical specialist to appear on national TV


Leeds native turned children’s medical specialist to appear on national TV
DR. LISA EMRICK
Published: 2/23/2021 11:59:34 AM
NORTHAMPTON Joel Emrick of Leeds says his daughter Lisa wanted to be a doctor from an early age.
Today, as a specialist in pediatric medicine, neurology, genetics and neurodevelopment disease, Dr. Lisa Emrick has long since fulfilled her childhood dream. And on Wednesday at 3 p.m., she’ll go on national television to talk about some of her work.
Dr. Emrick, who lives outside Houston, will appear on the syndicated talk show “The Doctors,” a program on which medical professionals discuss a range of health and medical issues. The show is a spin-off of the long-running “Dr. Phil” show. ....

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ALS neuron damage reversed with new compound


After 60 days of treatment, diseased brain cells look like healthy cells
More research needed before clinical trial can be initiated
CHICAGO and EVANSTON - Northwestern University scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a swift and fatal neurodegenerative disease that paralyzes its victims.
In addition to ALS, upper motor neuron degeneration also results in other motor neuron diseases, such as hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS).
In ALS, movement-initiating nerve cells in the brain (upper motor neurons) and muscle-controlling nerve cells in the spinal cord (lower motor neurons) die. The disease results in rapidly progressing paralysis and death. ....

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First "Race, Ethnicity and Alzheimer's in America" Report and Updated 2021 Alzheimer's Facts & Figures Report


Expert Pitch
First “Race, Ethnicity and Alzheimer’s in America” Report and Updated 2021 Alzheimer’s Facts & Figures Report
Race, Ethnicity and Alzheimer’s in America,” will be released March 2.
Facts and Figures provides in-depth information on Alzheimer’s and other dementias in the U.S., including the latest stats on prevalence, mortality, costs, caregiving and other insights both nationally and with state by state data. Alzheimer’s and dementia impacts approximately 1 in 9 adults aged 65 and older in the U.S.  Black Americans are twice - and Hispanic Americans one and a half times - as likely as to have Alzheimer’s than whites.    ....

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'Walking' molecule superstructures could help create neurons for regenerative medicine


Credit: Stupp Lab / Northwestern University
Imagine if surgeons could transplant healthy neurons into patients living with neurodegenerative diseases or brain and spinal cord injuries. And imagine if they could grow these neurons in the laboratory from a patient s own cells using a synthetic, highly bioactive material that is suitable for 3D printing.
By discovering a new printable biomaterial that can mimic properties of brain tissue, Northwestern University researchers are now closer to developing a platform capable of treating these conditions using regenerative medicine.
A key ingredient to the discovery is the ability to control the self-assembly processes of molecules within the material, enabling the researchers to modify the structure and functions of the systems from the nanoscale to the scale of visible features. The laboratory of Samuel I. Stupp published a 2018 paper in the journal ....

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