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'Mini brain' organoids grown in lab mature much like infant brains

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IMAGE: A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived mini brain organoids can mature in a manner that is strikingly similar to human brain.
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Credit: UCLA Health
A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived organoids can mature in a manner that is strikingly similar to human brain development.
For the new study, published in
Nature Neuroscience February 22, senior authors Dr. Daniel Geschwind of UCLA and Dr. Sergiu Pasca of Stanford University conducted extensive genetic analysis of organoids that had been grown for up to 20 months in a lab dish. They found that these 3D organoids follow an internal clock that guides their maturation in sync with the timeline of human development. ....

Daniel Geschwind , Aaron Gordon , Sergiu Pasca , Stem Cell Research , David Geffen School Of Medicine , Geschwind Lab , Stanford University , Edythe Broad Center , Institute For Precision Health , Nature Neuroscience February , Macdonald Distinguished Professor , Human Genetics , David Geffen School , Regenerative Medicine , Precision Health , Medicine Health , ஆரோன் கோர்டந் , தண்டு செல் ஆராய்ச்சி , டேவிட் கெஃப்ஃபெந் பள்ளி ஆஃப் மருந்து , ஸ்டான்போர்ட் பல்கலைக்கழகம் , எதய்ததே பரந்த மையம் , நிறுவனம் க்கு ப்ரிஸிஶந் ஆரோக்கியம் , இயற்கை நரம்பியல் பிப்ரவரி , மெக்டொனால்ட் புகழ்பெற்ற ப்ரொஃபெஸர் , மனிதன் ஜெநெடிக்ஸ் , டேவிட் கெஃப்ஃபெந் பள்ளி ,

Immune-compromised people with HIV, APOE4 gene may have a compounded risk for Alzheimer's

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WASHINGTON (Feb. 22, 2021) - People living with the human immunodeficiency virus (HIV) who have a history of severe immunosuppression and at least one copy of the Alzheimer s disease-related gene variant APOE4, might see a compounded adverse effect on the circuitry that impacts memory. This could eventually lead to an increased risk for dementia after age 65, according to Georgetown University Medical Center investigators and colleagues.
The researchers used MRI scans to examine the brain, with a focus on two regions - the hippocampus, which is critical for memory and is often affected in Alzheimer s disease, and the caudate nucleus, which sits deep in the center of the brain and is often affected in people with HIV. Based on the MRI images, they found that connectivity between the two regions was affected by APOE4 in people with HIV. A history of severe immunosuppression further exacerbated the impact of APOE4. ....

Georgetown University , District Of Columbia , United States , San Diego , Princy Kumar , R Scott Turner , Margarita Bronshteyn , Nils Yang , Davidj Moore , Ronaldj Ellis , Matthew Dawson , Xiong Jiang , G William Rebeck , University Of California , Cognitive Neuroimaging Laboratory , Georgetown University Medical Center , National Institutes Of Health , Cognitive Neuroimaging , Fan Nils Yang , National Institutes , Medicine Health , Alzheimers Disease , ஜார்ஜ்டவுன் பல்கலைக்கழகம் , மாவட்டம் ஆஃப் கொலம்பியா , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ ,

Johns Hopkins neuroscientist wins Barancik Prize for Innovation in MS Research

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IMAGE: Dwight E. Bergles, Ph.D., a leading neuroscientist at Johns Hopkins University School of Medicine, is the winner of the 2020 Barancik Prize for Innovation in MS Research. Bergles has pioneered.
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Credit: Courtesy Johns Hopkins University School of Medicine
NEW YORK, February 18, 2021 Dwight E. Bergles, Ph.D., a leading neuroscientist at The Solomon H. Snyder Department of Neuroscience and the Kavli Neuroscience Discovery Institute at Johns Hopkins University School of Medicine, is the winner of the 2020 Barancik Prize for Innovation in MS Research.
Bergles has pioneered the study of immature cells in the brain that can regenerate myelin-making cells after myelin is destroyed in MS. These cells, oligodendrocyte precursor cells (OPCs), hold the key to finding ways to promote myelin repair and restore function for people living with multiple sclerosis. ....

Bruce Bebo , Dwighte Bergles , Johns Hopkins , Americas Committee For Treatment , National Multiple Sclerosis Society , Ms Research , Behavior Research Foundation , Forum On , Science University In Portland , Research In Multiple Sclerosis , Margery Barancik Foundation , Research Programs , Boston University , Alfredp Sloan Foundation Research Fellowship , Solomonh Snyder Department Of Neuroscience , National Ms Society , Stanford University , Kavli Neuroscience Discovery Institute , Johns Hopkins University School , Executive Vice President , Vollum Institute , Advanced Biomedical Research , Oregon Health , Science University , Barancik Prize , Foundation Research Fellowship ,

Understanding the dynamics of brain blood flow could hold key for treating neurologic conditions

Understanding the dynamics of brain blood flow could hold key for treating neurologic conditions
While the human brain has over 400 miles of total vasculature, little is known about the tiny capillaries that make up much of this intricate labyrinth of blood vessels critical for delivering oxygenated blood and nutrients to billions of brain cells.
According to Dr. Andy Shih, a principal investigator in the Center for Developmental Biology and Regenerative Medicine at Seattle Children s Research Institute, understanding how this vast network regulates blood flow in the brain could hold the key to new treatments for neonatal and childhood neurologic conditions, such as stroke and hypoxia, and issues of aging like dementia and Alzheimer s disease. ....

David Hartmann , Andy Shih , Andree Anne Berthiaume , Emily Henderson , Regenerative Medicine At Seattle Children Research Institute , Seattle Children Research Institute , Stanford University , Developmental Biology , Regenerative Medicine , Seattle Children , Research Institute , Study Principal Investigator , Nature Neuroscience , Juliane Gust , Alzheimer 39s Disease , Blood Vessels , Clinical Imaging , Imaging Techniques , In Vivo , Opto Genetics , டேவிட் ஹார்ட்மேன் , ஆண்டி ஷிஹ் , அன்றேல் அன்னே பெர்த்தியாம் , எமிலி ஹென்டர்சன் , மீளுருவாக்கம் மருந்து இல் சீட்டில் குழந்தைகள் ஆராய்ச்சி நிறுவனம் , சீட்டில் குழந்தைகள் ஆராய்ச்சி நிறுவனம் ,

Researchers uncover new information on effects of antidepressants - drugs bind directly to a brain-derived neurotrophic factor

The findings of a new study challenge the prevailing thinking on the primary role of serotonin and other neurotransmitters in the effects of. ....

Eteläuomen Läi , Southwest Finland , Kainuu Region , Eero Castr , Ilpo Vattulainen , University Of Helsinki , Neuroscience Center , Department Of Physics , Professor Eero Castr , Professor Ilpo Vattulainen , Nervous System , Cell Membrane , தென்மேற்கு பின்லாந்து , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , நரம்பியல் மையம் , துறை ஆஃப் இயற்பியல் , பதட்டமாக அமைப்பு , செல் சவ்வு ,