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Improving stroke treatment with a modified therapeutic molecule

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IMAGE: INRS Professor Marc A. Gauthier is a specialist in dynamic chemistry, bioorganic chemistry and biomaterials.
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Credit: Christian Fleury (INRS)
A research team from the Institut national de la recherche scientifique (INRS) has improved the protective effect of a molecule against ischemic stroke, which is caused by an interruption of blood flow to the brain. The results of the study, conducted in collaboration with a Spanish team, were published in the
Communications Biology of Nature Research journal.
Every year in Quebec, about 20,000 people have a stroke. Also known as a cerebral infarction , this sudden neurological deficit can lead to psychological and physical after-effects. These effects result from an increase in glutamate in the brain, which destroys neurons. Glutamate is an essential neurotransmitter for neuronal communication, learning and memory processes, yet above a certain concentration, it becomes toxic to ....

Andreaa Greschner , Antonio Dopico , Pablo Hervella , Marca Gauthier , Armand Frappier Sant , Ahlem Zaghmi , Francisco Campos , Terre Environnement , Communications Biology Of Nature Research , Engineering Research Council Of Canada , Natural Sciences , Communications Biology , Nature Research , Professor Marc , Professor Gauthier , Antonio Dopico L , Ana Bugallo Casal , Engineering Research Council , Quebec City , Eau Terre Environnement , Urbanisation Culture Soci , Biomedical Environmental Chemical Engineering , Chemistry Physics Materials Sciences , Pharmaceutical Sciences , Pharmaceutical Combinatorial Chemistry , Polymer Chemistry ,

Researchers launch program to diagnose genetic diseases in children

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Researchers launch program to diagnose genetic diseases in children
A new University of Alberta pilot program aims to find answers and better treatments for children living with rare genetic conditions.
The Undiagnosed Disease Program, launched in January, is a collaboration between the Women and Children’s Health Research Institute (WCHRI) and U of A researchers from medical genetics and pediatric neurology to provide a diagnosis to patients in the health system who are suspected to have a genetic condition that has not been identified.
“Patients see doctor after doctor, and usually are treated for their symptoms, but an overall diagnosis hasn’t been made,” explained project lead Peter Kannu, chair of the Department of Medical Genetics in the Faculty of Medicine & Dentistry. “The concept of the Undiagnosed Disease Program has been operational at many other institutions in North America, and it will be a service that caters to these patients her ....

United States , Helly Goez , Alison Eaton , Peter Kannu , Department Of Medical Genetics , University Of Alberta , Stollery Children Hospital Foundation , Children Health Research Institute , Disease Program , Undiagnosed Disease Program , Health Research Institute , Medical Genetics , North America , Stollery Children , Hospital Foundation , Health Research , Rare Disease Day , Genetic Testing , ஒன்றுபட்டது மாநிலங்களில் , அலிசன் ஈட்டன் , பீட்டர் கண்ணு , துறை ஆஃப் மருத்துவ ஜெநெடிக்ஸ் , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா , குழந்தைகள் ஆரோக்கியம் ஆராய்ச்சி நிறுவனம் , நோய் ப்ரோக்ர்யாம் , ஆரோக்கியம் ஆராய்ச்சி நிறுவனம் ,

Study finds real-time dialogue with a dreaming person is possible

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IMAGE: This photo shows Konkoly watching brain signals from a sleeping participant in the lab. Researchers are working to expand and refine two-way communications with sleeping people so more complex conversations.
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Credit: K. Konkoly
Dreams take us to what feels like a different reality. They also happen while we re fast asleep. So, you might not expect that a person in the midst of a vivid dream would be able to perceive questions and provide answers to them. But a new study reported in the journal
Current Biology on February 18 shows that, in fact, they can.
We found that individuals in REM sleep can interact with an experimenter and engage in real-time communication, said senior author Ken Paller (@kap101) of Northwestern University. We also showed that dreamers are capable of comprehending questions, engaging in working-memory operations, and producing answers. ....

Karen Konkoly , Ken Paller , Stiftung Osnabr , Radboud University Medical Center , Sorbonne University , Netherlands Organisation For Scientific Research , Science Foundation , National Science Foundation , Northwestern University , Current Biology , Mind Science Foundation , Netherlands Organisation , Scientific Research , European Cooperation , Cell Press , Medicine Health , Sleep Disorders , கேன் பாலிலேர் , சோர்போன் பல்கலைக்கழகம் , நெதர்லாந்து ஆர்கநைஸேஶந் க்கு அறிவியல் ஆராய்ச்சி , அறிவியல் அடித்தளம் , தேசிய அறிவியல் அடித்தளம் , வடமேற்கு பல்கலைக்கழகம் , தற்போதைய உயிரியல் , மனம் அறிவியல் அடித்தளம் , நெதர்லாந்து ஆர்கநைஸேஶந் ,

Human brain taps into visual cues when lacking a sense of touch - study

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Evidence that a sense of our physical selves can develop even without the sense of touch has been uncovered in a new study by researchers in the UK and the United States.
The research shows that if someone loses their sense of touch and proprioception - their sense of body position - as an adult, they may learn compensatory skills using visual cues and conscious thought, or reasoning, to move their bodies.
Someone who has never had a sense of touch or proprioception, however, can find faster, unconscious ways of processing visual cues to move and orient themselves.
A team at the University of Birmingham collaborated with researchers at Bournemouth University and the University of Chicago on the study, published in ....

United States , United Kingdom , Jonathan Cole , Peggy Mason , Tony Moran , Chris Miall , Professor Of Clinical Neurophysiology At Bournemouth University , Experimental Brain Research , Bournemouth University , University Of Chicago , International Communications , University Of Birmingham , Experimental Brain , Motor Neuroscience , Clinical Neurophysiology , International Communications Manager , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , ஜொனாதன் கோல் , பெக்கி கொத்தனார் , டோனி மோரன் , ப்ரொஃபெஸர் ஆஃப் மருத்துவ நரம்பியல் இல் போர்ன்மவுத் பல்கலைக்கழகம் , சோதனை மூளை ஆராய்ச்சி , போர்ன்மவுத் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் சிகாகோ ,

Researchers measure baseline activity of single neurons

Researchers measure baseline activity of single neurons
Our brains are complicated webs of billions of neurons, constantly transmitting information across synapses, and this communication underlies our every thought and movement.
But what happens to the circuit when a neuron dies? Can other neurons around it pick up the slack to maintain the same level of function?
Indeed they can, but not all neurons have this capacity, according to new research from the University of Chicago. By studying several neuron pairs that innervate distinct muscles in a fruit fly model, researchers found that some neurons compensate for the loss of a neighboring partner. ....

Robert Carrillo , Yupu Wang , Emily Henderson , Committee On Development , University Of Chicago , Molecular Genetics , Cell Biology , Graduate Studies , Stem Cell , Motor Neurons , Neurodegenerative Diseases , ராபர்ட் கரில்லோ , எமிலி ஹென்டர்சன் , குழு ஆன் வளர்ச்சி , பல்கலைக்கழகம் ஆஃப் சிகாகோ , மூலக்கூறு ஜெநெடிக்ஸ் , செல் உயிரியல் , பட்டதாரி ஆய்வுகள் , தண்டு செல் ,