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Research pinpoints unique drug target in antibiotic resistant bacteria

Researchers have identified a critical mechanism that allows deadly bacteria to gain resistance to antibiotics.
The findings offer a potential new drug target in the search for effective new antibiotics as we face the growing threat of antimicrobial resistance (AMR) and infections caused by bacterial pathogens.
The study investigated quinolone antibiotics which are used to treat a range of bacterial infections, including TB (tuberculosis). Quinolones work by inhibiting bacterial enzymes, gyrase and topoisomerase IV, thereby preventing DNA replication and RNA synthesis essential to growth.
They are highly-successful antimicrobial agents widely used in current medicine, however bacterial resistance to them and other treatments is a serious problem. ....

Tony Maxwell , Centre Of Excellence , National Natural Science Foundation Of China , University Of Tokyo , Technology Of China , Ministry Of Science , John Innes Centre , Professor Tony Maxwell , Wellcome Trust , Microbial Science , National Natural Science Foundation , International Joint Research Project , Medical Science , Professor Maxwell , Molecular Biology , Medicine Health , Pharmaceutical Science , டோனி மேக்ஸ்வெல் , மையம் ஆஃப் சிறப்பானது , தேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனா , பல்கலைக்கழகம் ஆஃப் டோக்கியோ , தொழில்நுட்பம் ஆஃப் சீனா , அமைச்சகம் ஆஃப் அறிவியல் , ஜான் இநெஸ் மையம் , ப்ரொஃபெஸர் டோனி மேக்ஸ்வெல் , வெல்கம் நம்பிக்கை ,

Fruit fly research part of effort to protect human health from toxic chemicals

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IMAGE: Robert Anholt and Trudy Mackay in a lab holding a test tube containing Drosophila melanogaster, the common fruit fly.
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Credit: Clemson University College of Science
Researchers Trudy Mackay and Robert Anholt of the Clemson University Center for Human Genetics have joined forces with an international consortium intended to drive research that will shape regulation and policy on chemical safety without the use of animal testing.
Mackay, an internationally renowned scientist and director of the Center for Human Genetics (CHG), will team with Anholt to explore the genetic underpinnings of susceptibility to environmental toxicants using Drosophila melanogaster, the common fruit fly. ....

United States , United Kingdom , Baden Wuberg , John Colbourne , Karlsruher Institut , Robert Anholt , Trudy Mackay , Genetic Reference Panel , Michabo Health Science Ltd , European Commission Horizon , University Of Birmingham , Clemson University College Of Science , Clemson University Research Foundation , Clemson University Center , Clemson Division Of Research , Indiana University , University Of Oxford , College Of Science , European Commission , Fundacio Centre De Regulacio Genomica , Greenwood Sc Genetic Center , Cell Networks , Acondicionamieto Tarrasense Association , Researchers Trudy Mackay , Human Genetics , Distinguished Professor ,

Precision Toxicology consortium to protect human health from effects of harmful chemicals

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A major research project to shape regulation and policy on chemical safety without the use of animal testing has been launched with the aid of €19.3M funding from the European Commission.
Led by the University of Birmingham and involving 15 European and US organisations, PrecisionTox aims to protect human health from the toxic effects of chemicals found in people s homes, food and the environment.
The consortium will use genetics, genomics, metabolomics and the study of evolution to investigate the toxicity of hundreds of chemicals and explore how they disrupt the biological processes that are fundamental to health. Combined with law, these approaches will open up a new field of precision toxicology that will transform approaches to chemical safety management in the same way that precision medicine is informing healthcare. In particular, it is expected that precision toxicology will be instrumental in shaping policy and regulation of this field. ....

John Colbourne , Karlsruher Institut , Umweltforschung Gmb , Richard Fuller , Acondicionamiento Tarrasense Associacion , Indiana University , Michabo Health Science Ltd , University Of Oxford , Fundacio Centre De Regulacio Genomics , European Commission , University Of Birmingham , Cell Networks Gmb , Centre For Precision Toxicology , Clemson University , Lancet Commission , University Of Heidelberg , Pure Earth , Grant Agreement , Data Commons , Helmholtz Zentrum , Umweltforschung Gmbh , Cell Networks Gmbh , Fertilizers Pest Management , Ecology Environment , Molecular Biology , Pollution Remediation ,

Floral probiotics reduce apple disease

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IMAGE: Researchers applying probiotic sprays to blooming apple trees at the Connecticut Agricultural Experiment Station.
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Credit: Zhouqi Cui, Regan B. Huntley, Neil P. Schultes, Blaire Steven, and Quan Zeng
While many celebrate apple blossoms as classic signs of spring, they are also welcoming entry gates for pathogens. Full of nutrients to lure pollinators and promote pollen germination, flowers also attract bacteria like
Erwinia amylavora, a pathogen that causes a damaging disease called fire blight. However, recent work by scientists at the Connecticut Agricultural Experiment Station suggests that these flowery infection sites might also be perfect targets for applying microbial fire blight biocontrol measures. ....

University Of Connecticut , United States , Zhouqi Cui , Quan Zeng , Mia Howard , Jen Lau , Blaire Steven , Neil Schultes , Regan Huntley , Zhouqi Cui Cuizhouqi , Indiana University , Department Of Plant Pathology , Department Of Plant Science , Connecticut Agricultural Experiment Station , Phytobiomes Journal , Stigma Colonizing Microbes , Apple Stigmas Alters Microbiome Structure , Fire Blight Disease , Associate Scientist , Plant Pathology , Plant Science , Landscape Architecture , Agricultural Production Economics , Food Science , Plant Sciences , Ecology Environment ,

3 medical innovations fueled by COVID-19 that will outlast the pandemic

The coronavirus pandemic has driven a lot of scientific progress in the past year. But just as some of the social changes are likely here to stay, so are some medical innovations. ....

United States , San Francisco , Alberth Titus , Aplidin Plitidepsin , Nevan Krogan , University Of California , University Of Washington , Quantitative Biosciences Institute , University At Buffalo , Coronavirus Research Group , Biomedical Engineering , Research Group , Cellular Molecular Pharmacology , Apple Watch , Covid 19 , Corona Virus , Drug Discovery , Early Detection , Immune Response , Innovation And Invention , Sars Cov 2 , ஒன்றுபட்டது மாநிலங்களில் , சான் பிரான்சிஸ்கோ , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் , அளவு உயிர் அறிவியல் நிறுவனம் ,