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David Julius and Ardem Patapoutian win the Frontiers of Knowledge Award in Biomedicine

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Credit: BBVA Foundation
The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this thirteenth edition to David Julius, from the University of California, San Francisco, and Ardem Patapoutian, from the Scripps Institute, La Jolla (United States), for identifying the receptors that enable us to sense temperature, pain and pressure.
Temperature, pain and pressure are part of our sense of touch, perhaps the least understood of the five main senses of humans, read the opening words of the citation. Julius and Patapoutian provided a molecular and neural basis for thermosensation and mechanosensation.
This line of research holds out exciting medical possibilities, because it sheds light on how to reduce chronic and acute pain associated with a range of diseases, trauma and their treatments. In fact, several pharmaceutical laboratories are working to identify molecules that act on these receptors with the aim of treati ....

New York , United States , United Kingdom , Los Angeles , San Francisco , Robert Francis Furchgott , Ardem Patapoutian , Celis Ibeas , Angelika Schnieke , Luis Mart , Dolores Gonz , Isabel Varela Nieto , David Julius , Dario Alessi , Robin Lovell , Ali Shilatifard , M Isabel Medina , Bruce Whitelaw , Department Of Cellular , Department Of Animal Sciences , Foundation Frontiers Of Knowledge , Genomics Institute Of The Novartis Research Foundation , National Advisory Neurological Disorders , Department Of Neuroscience , Neyra Institute Of Parasitology , Technical University Of Munich ,

Circadian clock shows 'Junk DNA' plays key role

Circadian clock shows 'Junk DNA' plays key role
sandiegosun.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sandiegosun.com Daily Mail and Mail on Sunday newspapers.

San Diego , United States , Caitlyn Miller , Steve Kay , Lili Zhou , Proceedings Of The National Academy Sciences , Keck School Of Medicine , Genomics Institute Of The Novartis Research Foundation , Keck School Department Of Neurology , National Academy , Provost Professor , Keck School , Genomics Institute , Novartis Research Foundation , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , கைட்லின் மில்லர் , ஸ்டீவ் காய் , லில்லி ஜூ , கேக்க் பள்ளி ஆஃப் மருந்து , மரபியல் நிறுவனம் ஆஃப் தி நோவர்த்திச் ஆராய்ச்சி அடித்தளம் , கேக்க் பள்ளி துறை ஆஃப் நரம்பியல் , தேசிய கலைக்கழகம் , புரோஸ்ட் ப்ரொஃபெஸர் , கேக்க் பள்ளி , மரபியல் நிறுவனம் ,

'Junk DNA' plays a key role in regulating circadian clocks

‘Junk DNA’ plays a key role in regulating circadian clocks
January 7, 2021USC
Study suggests the impact of non-coding microRNAs on circadian rhythms is tissue specific and may reveal new insights into disease processes.
If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function. Molecular circadian “clocks” exist in cells throughout the body, governing more than just sleep and wake cycles they are crucial to many aspects of human health. For more than a decade, researchers have been trying to figure out what makes them tick, in search of new insights into diseases like Alzheimer’s, cancer and diabetes. ....

San Diego , United States , Caitlyn Miller , Steve Kay , Lili Zhou , Proceedings Of The National Academy Sciences , Keck School Of Medicine , Genomics Institute Of The Novartis Research Foundation , Keck School Department Of Neurology , National Academy , Provost Professor , Keck School , Genomics Institute , Novartis Research Foundation , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , கைட்லின் மில்லர் , ஸ்டீவ் காய் , லில்லி ஜூ , கேக்க் பள்ளி ஆஃப் மருந்து , மரபியல் நிறுவனம் ஆஃப் தி நோவர்த்திச் ஆராய்ச்சி அடித்தளம் , கேக்க் பள்ளி துறை ஆஃப் நரம்பியல் , தேசிய கலைக்கழகம் , புரோஸ்ட் ப்ரொஃபெஸர் , கேக்க் பள்ளி , மரபியல் நிறுவனம் ,

'Junk DNA' plays a key role in regulating our circadian clocks

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‘Junk DNA’ plays a key role in regulating our circadian clocks
If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function. Molecular circadian “clocks” exist in cells throughout the body, governing more than just sleep and wake cycles they are crucial to many aspects of human health. For more than a decade, researchers have been trying to figure out what makes them tick, in search of new insights into diseases like Alzheimer’s, cancer and diabetes.
Until now, that research has focused on what is known as clock genes, which encode proteins that drive oscillating cycles of gene expression affecting physiology and behavior. But research just published in the Proceedings of the National Academy of Sciences reveals the discovery of a new cog in the circadian clock a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as micro RNAS (miRNAs). ....

San Diego , United States , Caitlyn Miller , Angelica Romero , Lorenj Miraglia , Steve Kay , Lili Zhou , National Institute Of Diabetes , Proceedings Of The National Academy Sciences , Keck School Of Medicine , Genomics Institute Of The Novartis Research Foundation , Keck School Department Of Neurology , National Academy , Provost Professor , Keck School , Genomics Institute , Novartis Research Foundation , Satchidananda Panda , Salk Institute , National Institute , Kidney Diseases Grant , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , கைட்லின் மில்லர் , ஏஞ்சலிகா ரொமெரோ , ஸ்டீவ் காய் ,

MicroRNAs Modulating Diurnal Rhythms in Cells Identified in Genome-Wide Study

MicroRNAs Modulating Diurnal Rhythms in Cells Identified in Genome-Wide Study
January 6, 2021
A new cell-based, genome-wide study has identified a cluster of micro RNAs (miRNAs) noncoding RNA molecules about 22 nucleotides long that constitute a new layer of modulation for clock genes responsible for circadian rhythms. Until now, most studies probing regulatory mechanisms of daily biological rhythms have focused on feedback loops that regulate protein-coding genes.
Regulation of circadian rhythms is key, not only in understanding sleep, but also diseases such as Alzheimer’s, cancer, and diabetes. Understanding how miRNAs regulate the circadian clock in different tissues and organs could reveal new therapeutic approaches. ....

University Of Southern California , United States , San Diego , Caitlyn Miller , Steve Kay , Lili Zhou , Proceedings Of The National Academy Sciences , Keck School Department , Genomics Institute Of The Novartis Research Foundation , National Academy , Keck School , Genomics Institute , Novartis Research Foundation , Southern California , பல்கலைக்கழகம் ஆஃப் தெற்கு கலிஃபோர்னியா , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ , கைட்லின் மில்லர் , ஸ்டீவ் காய் , லில்லி ஜூ , கேக்க் பள்ளி துறை , மரபியல் நிறுவனம் ஆஃப் தி நோவர்த்திச் ஆராய்ச்சி அடித்தளம் , தேசிய கலைக்கழகம் , கேக்க் பள்ளி , மரபியல் நிறுவனம் , நோவர்த்திச் ஆராய்ச்சி அடித்தளம் ,