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A CRISPR on-off switch for genes controls expression without altering DNA

April 12, 2021 A new gene silencing tool allows scientists to switch genes on and off without altering genetic sequences. The tool, described in a paper published in
Cell on April 9, uses a modified CRISPR-Cas9 system to introduce reversible epigenetic changes that control gene expression.
The classic CRISPR-Cas9 system led to an explosion in gene editing studies since it was first developed almost a decade ago. It became quickly popular thanks to its ease of use compared to previous gene editing methods.
CRISPR-Cas9 uses guide RNA to chaperone the Cas9 nuclease to a particular site in the DNA and create a double-strand break. By adding a specially designed short sequence of DNA, scientists can introduce permanent genetic changes to the cell. This oligonucleotide is used as a template by the cell when repairing the double-strand break, incorporating the sequence into the cell s genome. However, this approach can cause unintended genetic changes. ....

United States , San Francisco , Luke Gilbert , Jonathan Weissman , University Of California , Jennifer Cook Chrysos Whitehead Institute For Biomedical Research , Massachusetts Institute Of Technology , Massachusetts Institute , Whitehead Institute , Crispr Cas9 , Gene Editing Tools , Guide Rna , Epigenetic Changes , Gene Silencing , Transcriptional Repressor Proteins , Transcriptional Activator Domains , Fusion Proteins , Cas9 Proteins , ஒன்றுபட்டது மாநிலங்களில் , சான் பிரான்சிஸ்கோ , லூக் கில்பர்ட் , ஜொனாதன் வெயிஸ்மேன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , மாசசூசெட்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , மாசசூசெட்ஸ் நிறுவனம் , வைட்ஹெட் நிறுவனம் ,

Discovery of cryptic pocket in SARS-CoV-2 may lead to pan-coronavirus therapies

Discovery of cryptic pocket in SARS-CoV-2 may lead to pan-coronavirus therapies
Coronaviruses have been around for a long time and have caused several recent deadly outbreaks. The most recent is the ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
A new research paper published in the
Biophysical Journal describes a novel binding pocket used by a viral non-structural protein (nsp) to form an activated complex with its partner nsp. In so doing, it may have revealed a common target that may be useful in the development of a broad-spectrum antiviral drug against all coronaviruses. ....

Liji Thomas , Biophysical Journal , Corona Virus , Sars Cov 2 , Antiviral Drug , Coronavirus Disease Covid 19 , Protein Synthesis , Ribonucleic Acid , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Structural Protein , உயிர் இயற்பியல் இதழ் , கொரோனா வைரஸ் , சர்வதேச பரவல் , ப்ரோடீந் தொகுப்பு , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , கட்டமைப்பு ப்ரோடீந் ,

ALSF announces grant award recipients of Crazy 8 Initiative in pediatric oncology

ALSF announces grant award recipients of Crazy 8 Initiative in pediatric oncology
Alex s Lemonade Stand Foundation (ALSF), a nonprofit foundation devoted to finding cures for all children with cancer, announces grant award recipients of their Crazy 8 Initiative. The recipients will receive grants totaling more than $18.5 million, which is the single, largest funding commitment from ALSF to date.
The Initiative kicked off in the Fall of 2018 with a meeting that brought together more than 90 scientists from around the world to help define the research landscape in eight key areas of need in order to tackle major obstacles impeding progress toward cures for childhood cancer. Through a rigorous review process, ALSF received over 100 letters of intent from researchers that resulted in 83 full grant applications which were ultimately narrowed down to four projects that will work to accelerate the pace of new cure discovery. ....

United States , Seychelle Vos , Yaelp Moss , Jefferym Klco , Leonard Zon , Ross Levine , Emily Henderson , Klimenta Verba , Liz Scott , Zoran Rankovic , Peter Campbell , Igor Adameyko , Martin Eilers , Matthias Farlik , Martin Distel , Scotta Armstrong , Paula Northcott , Fernando Camargo , John Maris , Natalia Jura , Gwenn Hansen , Florian Halbritter , Charlesg Mullighan , Williama Weiss , M Madan Babu , Juerg Schwaller ,

Backtracking occurs within SARS-CoV-2 replication-transcription complex

Researchers continue to achieve a better understanding of SARS-CoV-2, the virus behind the ongoing COVID-19 pandemic. One such effort has been reported in a new preprint on the bioRxiv server, dealing with the phenomenon of backtracking. ....

Ddrp Btcs , Liji Thomas , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Study targets main protease of SARS-CoV-2 involved in viral replication

The main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enzyme implicated in the transcription and replication of the coronavirus. New research led by S. Samar Hasnain from the University of Liverpool in the United Kingdom used the selenium-containing drug Ebselen to analyze the SARS-CoV-2 main protease (Mpro). ....

United Kingdom , Jocelyn Solis Moreiramar , Jocelyn Solis Moreira , University Of Liverpool , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது கிஂக்டம் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , பல்கலைக்கழகம் ஆஃப் லிவர்பூல் , கொரோனா வைரஸ் , எதிர் மின்னணு , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,