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PerkinElmer Adds HPLC Columns to Consumables Portfolio

PerkinElmer adds state-of-the-art columns and chemistries to its LC consumables, instrument and software portfolio to deliver end-to-end solutions. ....

United Kingdom , West Berlin , New Jersey , United States , Suneet Chadha , Odes Industries , Exchange Commission , European Union , Perkinelmer Inc , Applied Markets , Private Securities Litigation Reform Act , Media Contact , Testing Labs , Supercritical Fluid Chromatography , One Source , Health Care , Life Sciences , ஒன்றுபட்டது கிஂக்டம் , மேற்கு பெர்லின் , புதியது ஜெர்சி , ஒன்றுபட்டது மாநிலங்களில் , சுநீட் சதா , எஸ் தொழில்கள் , பரிமாற்றம் தரகு , ஐரோப்பிய தொழிற்சங்கம் , பயன்படுத்தப்பட்டது சந்தைகள் ,

Detecting hidden circulating tumor cells in non-small cell lung cancer patients

ISB and a collaborative team of researchers looked at hexokinase-2, or HK2, a key enzyme in glucose metabolism. A set of previous reports from our collaborator Dr. Herschman (co-author of the paper) and others revealed that cancer cells often rely on HK2 to elevate glucose metabolism to fuel their uncontrolled growth, making this enzyme a desirable target for testing, said ISB Assistant Professor Dr. Wei Wei, the lead corresponding author of the paper.
Conventional CTC detection methods, as exemplified by the FDA-cleared CellSearch system, normally rely on the use of a family of proteins called cytokeratins (CKs) that are typically found in epithelial tissues. As roughly 90 percent of human cancers arise in epithelial tissues and express CKs, these methods work very well in many major cancer types. However, their performance in NSCLC is suboptimal, despite the highly aggressive nature of NSCLC, which represents a long-standing puzzle in this field. ....

Harvey Herschman , Qihui Shi , University Of California Los Angeles , Shanghai Jiao Tong University , Proceedings Of The National Academy Sciences , Fudan University , Non Small Cell Lung Cancer , National Academy , California Los Angeles , Cell Biology , Medicine Health , Health Care Systems Services , Public Health , Smoking Tobacco , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா லாஸ் ஏஞ்சல்ஸ் , ஷாங்காய் ஜியாவோ நாக்கு பல்கலைக்கழகம் , அல்லாத சிறிய செல் நுரையீரல் புற்றுநோய் , தேசிய கலைக்கழகம் , கலிஃபோர்னியா லாஸ் ஏஞ்சல்ஸ் , உயிரி தொழில்நுட்பவியல் , செல் உயிரியல் , மருந்து ஆரோக்கியம் , ஆரோக்கியம் பராமரிப்பு அமைப்புகள் சேவைகள் , பொது ஆரோக்கியம் , புகைத்தல் புகையிலை , உயிர் தகவலியல் ,

Making the role of AI in medicine explainable

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IMAGE: Detection of tumor-infiltrating lymphocytes (TILs) using explainable AI. The AI-technique is used to generate a heatmap showing TILs (red) and other tissues and cells (blue and green).
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Credit: Image: Klauschen/Charité
Researchers at Charité - Universitätsmedizin Berlin and TU Berlin as well as the University of Oslo have developed a new tissue-section analysis system for diagnosing breast cancer based on artificial intelligence (AI). Two further developments make this system unique: For the first time, morphological, molecular and histological data are integrated in a single analysis. Secondly, the system provides a clarification of the AI decision process in the form of heatmaps. Pixel by pixel, these heatmaps show which visual information influenced the AI decision process and to what extent, thus enabling doctors to understand and assess the plausibility of the results of the AI analysis. This represents a decisive and esse ....

Nat Mach Intell , Frederick Klauschen , Institute Of Pathology , University Of Oslo , Nature Machine , Berlin Institute , Mach Intell , Cell Biology , Medicine Health , Breast Cancer , Health Care Systems Services , Robotry Artificial Intelligence , நாட் மச் இன்டெல் , நிறுவனம் ஆஃப் நோயியல் , பல்கலைக்கழகம் ஆஃப் ஒசிலோ , இயற்கை இயந்திரம் , பெர்லின் நிறுவனம் , மச் இன்டெல் , செல் உயிரியல் , மருந்து ஆரோக்கியம் , மார்பக புற்றுநோய் , ஆரோக்கியம் பராமரிப்பு அமைப்புகள் சேவைகள் ,

A new predictive model helps identify those at risk for severe COVID-19

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Researchers at the Buck Institute analyzed data from the COVID-19 Symptom Tracker app used by 3 million people in the United Kingdom, adding the use of immunosuppressant medication, use of a mobility aid, shortness of breath, fever, and fatigue to the list of symptoms and comorbidities that increase the risk for severe COVID-19. Results are published in the
Even though there are established risk factors for severe COVID-19 there are no good predictors that enable healthcare providers, or even those who have tested positive, to assess who should seek advanced medical care, says Buck Institute Associate Professor David Furman, PhD, the senior scientist who led the study. We are glad to add to the efforts underway around the world to determine how to best care for those infected by the coronavirus. ....

United Kingdom , City Of , Kari Nadeau , Eric Verdin , Dina Radenkovic , Kevin Perez , Yingxiang Huang , King College London , Buck Institute Associate Professor David Furman , Buck Institute , Other Buck Institute , Journal Of Medical Internet Research , Stanford University , Medical Internet , Seeking Treatment , Modeling Predictive Age Dependent , Independent Symptoms , College London , Palo Alto , Medicine Health , Infectious Emerging Diseases , ஒன்றுபட்டது கிஂக்டம் , நகரம் ஆஃப் , காரி நாடிெஓ , எரிக் வெர்டின் , கெவின் பெரெஸ் ,

New app developed to choose the best therapy for each dementia patient

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Every three seconds, a new case of dementia is diagnosed somewhere in the world. The term encompasses a group of neurodegenerative diseases that have no cure and which affect memory, cognitive abilities and behaviour, and includes Alzheimer s disease. According to World Health Organization (WHO) data, it is estimated that dementia affects about 50 million people around the world. With increasing life expectancy and an ageing population, this figure is expected to increase to 75 million by 2030 and 132 million by 2050.
Dementias cause disability and dependence, they have an enormous impact on those who suffer them and their caregivers, and raise considerable challenges for the sustainability of social protection systems. Although a number of drug therapies are available for treating the symptoms, psychosocial interventions help slow down the rate of progression and counteract the aspects that impair the quality of life of the sufferers and their caregivers. Through ....

Carme Carrion , Marta Aymerich , Catalan Government Health Plan , Health Lab , Catalan Health Institute , Agenda For Sustainable Development , Internet Interdisciplinary Institute , World Health Organization , Pompeu Fabra University , Health Institute , Institute Of Healthcare , Agency For Health Quality , University Of Girona Ud , Health Center , Sustainable Development Goals , Universitat Oberta De Catalunya , Health Quality , Catalan Government , Health Plan , United Nation , Sustainable Development , Medicine Health , Death Dying , Mortality Longevity , Alzheimers Disease , Disease In The Developing World ,